NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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5-(1,2-dithiolan-3-yl)pentanoic acid
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IUPAC Traditional name
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6,8-thioctic acid
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thioctic acid dl-form
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Synonyms
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(±)-1,2-Dithiolane-3-pentanoic acid
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6,8-Dithiooctanoic acid
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DL-α-Lipoic acid
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DL-6,8-Thioctic acid
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Lip(S2)
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(±)-α-Lipoic acid
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5-(1,2-Dithiolan-3-yl)pentanoic acid
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α-Lipoic acid
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DL-THIOCTIC ACID
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(+/-)-1,2-Dithiolane-3-pentanoic Acid
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(+/-)-1,2-Dithiolane-3-valeric Acid
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(+/-)-Thioctic Acid
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(RS)-α-Lipoic Acid
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DL-Thioctic Acid
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Liposan
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Lipothion
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NSC 628502
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NSC 90788
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Protogen A
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Thioctsan
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Tioctacid
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rac α-Lipoic Acid
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1,2-Dithiolane-3-valeric acid
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DL-6,8-Dithiooctanoic acid
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DL-Thioctic acid
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(±)-1,2-二硫戊环基-3-戊酸
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6,8-二巯基辛酸
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DL-α-硫辛酸
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DL-6,8-硫辛酸
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(±)-α-硫辛酸
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DL-硫辛酸
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CAS Number
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EC Number
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MDL Number
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Beilstein Number
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Merck Index
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
H Donor
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1
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LogD (pH = 5.5)
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1.0948822
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LogD (pH = 7.4)
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-0.6761287
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Log P
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2.1137793
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Molar Refractivity
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54.3714 cm3
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Polarizability
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21.431002 Å3
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Polar Surface Area
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37.3 Å2
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Rotatable Bonds
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5
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Lipinski's Rule of Five
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true
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Acid pKa
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4.523468
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H Acceptors
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2
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DETAILS
DETAILS
MP Biomedicals
Sigma Aldrich
TRC
Sigma Aldrich -
T1395
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Other Notes 氧化形式 Biochem/physiol Actions 维持酶复合物(例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物)活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后,该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子(尤其是 NF-κB)的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。 |
Sigma Aldrich -
62320
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Other Notes Review1 Packaging 5, 25 g in glass bottle Biochem/physiol Actions Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages. |
Sigma Aldrich -
T5625
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包装 1, 5, 25, 50 g in poly bottle 500 mg in poly bottle Biochem/physiol Actions 维持酶复合物(例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物)活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后,该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子(尤其是 NF-κB)的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。 |
PATENTS
PATENTS
PubChem Patent
Google Patent