(±)-α-Lipoic acid

• Catalog No.: 62320
• CAS Number: 1077-28-7
• M. F.: C8H14O2S2
• M. W.: 206.32556
• Purity: ≥98.0% (HPLC)

SYNONYMS

• Title: (±)-α-硫辛酸
• IUPAC name: 5-(1,2-dithiolan-3-yl)pentanoic acid
• IUPAC Traditional name: 6,8-thioctic acid
• Synonyms: (±)-1,2-Dithiolane-3-pentanoic acid; (±)-1,2-二硫戊环基-3-戊酸; DL-6,8-Thioctic acid; Lip(S2); DL-α-硫辛酸; 6,8-Dithiooctanoic acid; DL-α-Lipoic acid; 6,8-二巯基辛酸; DL-6,8-硫辛酸

DATABASE IDS

• MDL Number: MFCD00005474
• EC Number: 214-071-2
• PubChem SID: 24882156
• CAS Number: 1077-28-7
• Beilstein Number: 81853

PROPERTIES

• Empirical Formula (Hill Notation): C8H14O2S2
• Ignition Residue: ≤0.1%
• Loss on Drying: ≤0.1% loss on drying, 20 °C (HV)
• Purity: ≥98.0% (HPLC)
• Purity: ≥98.0%
• Gene Information: human ... ACHE(43), BCHE(590)rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)
• Melting Point: 60-62 °C
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• RTECS: JP1192000
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
Review1
Packaging
5, 25 g in glass bottle
Biochem/physiol Actions
Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages.

Description (简体中文)

Other Notes
综述1
包装
5, 25 g in glass bottle
Biochem/physiol Actions
维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物）活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后，该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子（尤其是 NF-κB）的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。