(±)-α-Lipoic acid

• Catalog No.: T1395
• CAS Number: 1077-28-7
• M. F.: C8H14O2S2
• M. W.: 206.32556
• Purity: ≥99%

SYNONYMS

• Title: (±)-α-硫辛酸
• IUPAC name: 5-(1,2-dithiolan-3-yl)pentanoic acid
• IUPAC Traditional name: 6,8-thioctic acid
• Synonyms: (±)-1,2-二硫戊环基-3-戊酸; Lip(S2); DL-α-硫辛酸; DL-6,8-硫辛酸; 6,8-二巯基辛酸

DATABASE IDS

• MDL Number: MFCD00005474
• EC Number: 214-071-2
• CAS Number: 1077-28-7
• PubChem SID: 24899963
• Beilstein Number: 81853

PROPERTIES

• Purity: ≥99%
• Suitability: cell culture tested
• Gene Information: human ... ACHE(43), BCHE(590)rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)
• Solubility: ethanol: soluble50 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• Risk Statements: 22
• RTECS: JP1192000
• German water hazard class: 3

DETAILS

Description (简体中文)

Other Notes
氧化形式
Biochem/physiol Actions
维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物）活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后，该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子（尤其是 NF-κB）的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。