Sulfathiazole

• Catalog No.: Bio-0804
• CAS Number: 72-14-0
• M. F.: C9H9N3O2S2
• M. W.: 255.31666

SYNONYMS

• IUPAC name: 4-amino-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide
• IUPAC Traditional name: 4-amino-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide
• Synonyms: Sultrin

DATABASE IDS

• CAS Number: 72-14-0

PROPERTIES

• Application(s): Sulfonamide
• Application(s): Used in treatment of severe staphylococcal infections, but use restricted due to its systemic toxicity.
• Mechanism of Action: Dihydrofolate reductase inhibitor
• Mechanism of Action: Dihydrofolate synthesis inhibitor
• Mechanism of Action: Folate-antagonist

REFERENCES

• Fosbinder, R.J., J.A.C.S., 1939, 61, 2032, (synth)
• Capitan, F. et al., Inf. Quim. Anal., 1970, 24, 100, (use)
• Bass, A.D. et al., Drill's Pharmacol. Med., 4th edn., McGraw-Hill, New York, 1971, 1657, (pharmacol)
• Kracmar, J. et al., Pharmazie, 1975, 30, 447, (uv)
• Forlani, L., Gazz. Chim. Ital., 1981, 111, 159, (pmr, tautom)
• Haley, T.J., Dangerous Prop. Ind. Mater. Rep., 1983, 3, 9, (rev, pharmacol, tox)
• Bult, A., Pharm. Weekbl., Sci. Ed., 1983, 5, 77, (cmr, tautom)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 1148
• Kirk-Othmer Encycl. Chem. Technol., 4th edn., Wiley, 1991, 2, 876, (rev)
• Kapoor, V.K., Anal. Profiles Drug Subst., 1993, 22, 389, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 210
• Hughes, D.S. et al., Acta Cryst. C, 1999, 55, 1831-1833, (cryst struct)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, TEX250; TEX500