Albendazole

• Catalog No.: Bio-0773
• CAS Number: 54965-21-8
• M. F.: C12H15N3O2S
• M. W.: 265.3314

SYNONYMS

• IUPAC name: methyl N-[5-(propylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbamate
• IUPAC Traditional name: methyl N-[5-(propylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbamate
• Synonyms: Zentel; Alben; Helmintal; Eskazole; Bermosol; Valbazen

DATABASE IDS

• CAS Number: 54965-21-8

PROPERTIES

• Application(s): Anthelmintic.
• Application(s): Investigated for treatment of chronic stronglyoidiasis, and for microsporidiosis in AIDS patients
• Mechanism of Action: Causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin,
• Mechanism of Action: thus inhibiting its polymerization or assembly into microtubules.
• Mechanism of Action: The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores.
• Mechanism of Action: Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP),
• Mechanism of Action: which is the energy required for the survival of the helminth.
• Mechanism of Action: Due to diminished energy production, the parasite is immobilized and eventually dies

REFERENCES

• U.S. Pat., 1975, SmithKline, 3 915 986; CA, 84, 31074r, (synth, pharmacol)
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• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 38
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• Oldfield, E.C., Am. J. Gastroenterol., 1995, 90, 159, (use)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, VAD000