Magnolol

• Catalog No.: Bio-0675
• CAS Number: 528-43-8
• M. F.: C18H18O2
• M. W.: 266.33432

SYNONYMS

• IUPAC name: 2-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol
• IUPAC Traditional name: 2-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol

DATABASE IDS

• CAS Number: 528-43-8

PROPERTIES

• Application(s): Antibacterial, antifungal agent
• Application(s): Antiplatelet agent
• Application(s): Sedative
• Application(s): Relaxant
• Application(s): Shows antiinflammatory and analgesic effects
• Biological Source: Constit. of Sassafras randaiense and Magnolia spp.
• Mechanism of Action: CNS depressant with serotonergic activity
• Mechanism of Action: Reported from in-vitro study in rat aorta to produce relaxation of vascular smooth-muscle mediated by: release of endothelium derived relaxant factor
• Mechanism of Action: Inhibition of calcium influx through voltage gated channels

REFERENCES

• Runeberg, J. et al., Acta Chem. Scand., 1957, 11, 1060; 1958, 12, 188
• Clark, A.M. et al., J. Pharm. Sci., 1981, 70, 951, (props)
• Wang, Y. et al., J. Chin. Chem. Soc. (Peking), 1982, 30, 215, (cryst struct)
• El-Feraly, F.S. et al., J. Nat. Prod., 1983, 46, 493
• Watanabe, K. et al., Planta Med., 1983, 49, 103, (isol, pharmacol)
• Hattori, M. et al., Chem. Pharm. Bull., 1984, 32, 5010; 1986, 34, 158, (metab)
• Ho, T.I. et al., CA, 1986, 105, 152803, (synth)
• Teng, C.-M. et al., Thromb. Res., 1988, 50, 757, (pharmacol)
• Wang, J.-P. et al., Naunyn-Schmiedeberg's Arch. Pharmacol., 1992, 346, 707, (pharmacol)
• Tsai, T.-H. et al., Drug Metab. Dispos., 1994, 22, 518, (hplc, pharmacokinet)
• Agharahimi, M.R. et al., J.O.C., 1995, 60, 1856, (synth, ir, pmr, cmr, ms)
• Tsai, T.-H. et al., Neurosci. Lett., 1995, 186, 49, (pharmacol)
• Kim, Y.-K. et al., Planta Med., 1996, 65, 291-292, (activity)