Ciprofloxacin

• Catalog No.: Bio-0540
• CAS Number: 85721-33-1
• M. F.: C17H18FN3O3
• M. W.: 331.3415232

SYNONYMS

• IUPAC name: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
• IUPAC Traditional name: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
• Synonyms: Velmonit; Flociprin; Baycip; Cilox; Ciprobay; Cipro; Belmacina; Catex; Ceprimax; Cetraxal; Ciflox; Ciloxan; Ciprok; Ciproxine; Estecina; Uniflox; Ciproxin; Cunesin; Rigoran; Septocipro

DATABASE IDS

• CAS Number: 85721-33-1

PROPERTIES

• Application(s): Broad spectrum antibacterial agent (used in treatment of Legionnaire's disease)
• Application(s): Provides postexposure protection against exp. inhalation anthrax ( Bacillus anthracis )
• Mechanism of Action: DNA gyrase (type II topoisomerase) and topoisomerase IV inhibitor

REFERENCES

• Ger. Pat., 1983, Bayer, 3 142 854; CA, 99, 53790h, (synth, pharmacol)
• Chin, N.X. et al., Antimicrob. Agents Chemother., 1984, 25, 319, (pharmacol)
• Curr. Clin. Pract. Ser., (Eds. Neu, H.C. et al), Excerpta Medica, 1986, (book)
• Ball, P., J. Antimicrob. Chemother., Suppl. D, 1986, 18, 187, (tox)
• Ciprofloxacin Product Information Monograph, M. Dekker, 1988, (book)
• Campoli-Richards, D.M. et al., Drugs, 1988, 35, 373, (rev)
• Vance-Bryan, K. et al., Clin. Pharmacokinet., 1990, 19, 434, (rev, pharmacokinet)
• New Gener. Quinolones, 1990, (Eds. Siporin, C. et al), M. Dekker (see Infect. Dis. Ther. v5 1990), 1990, (book)
• Textbook of Adverse Drug Reactions, 4th edn., (ed. Davies, D.M.), Oxford University Press, 1991, (tox)
• Mehta, A.C. et al., J. Clin. Pharm. Ther., 1992, 17, 117, (hplc)
• Friedlander, A.M. et al., J. Infect. Dis., 1993, 167, 1239-1243, (use)
• Wiseman, L.R. et al., Drugs Aging, 1994, 4, 145, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 5748, (synonyms)
• Davis, R. et al., Drugs, 1996, 51, 1019, (rev, pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 185
• Hay, A.M. et al., Synthesis, 1999, 1979-1985, (synth, uv, pmr)