Prulifloxacin

• Catalog No.: Bio-0141
• CAS Number: 5875-06-9
• M. F.: C21H20FN3O6S
• M. W.: 461.4634032

SYNONYMS

• IUPAC name: 6-fluoro-1-methyl-7-{4-[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl]piperazin-1-yl}-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
• IUPAC Traditional name: 6-fluoro-1-methyl-7-{4-[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl]piperazin-1-yl}-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

DATABASE IDS

• CAS Number: 5875-06-9

PROPERTIES

• Application(s): Antibacterial agent
• Application(s): Antiseptic
• Application(s): Prodrug
• Mechanism of Action: Blocker of bacterial DNA replication
• Mechanism of Action: Interference with DNA gyrase (supercoiling; reestablishment of DNA coil integrity during replication)

REFERENCES

• Eur. Pat., 1989, Nippon Shinyaku, 315 828; CA, 111, 194791, (synth, pharmacol)
• Ozaki, M. et al., Antimicrob. Agents Chemother., 1991, 35, 2496; 1992, 36, 1170; 1993, 37, 930
• Segawa, J. et al., J. Med. Chem., 1992, 35, 4727, (synth, pmr, ir, pharmacol)
• Nakashima, M. et al., J. Clin. Pharmacol., 1994, 34, 930, (pharmacokinet, man)