6-fluoro-1-methyl-7-{4-[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl]piperazin-1-yl}-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

• ChemBase ID: 124980
• Molecular Formular: C21H20FN3O6S
• Molecular Mass: 461.4634032
• Monoisotopic Mass: 461.1056846
• SMILES: c12n(c3c(c(=O)c1C(=O)O)cc(c(c3)N1CCN(Cc3oc(=O)oc3C)CC1)F)C(S2)C
• Canonical SMILES: O=c1oc(c(o1)CN1CCN(CC1)c1cc2c(cc1F)c(=O)c(c1n2C(C)S1)C(=O)O)C
• InChI: InChI=1S/C21H20FN3O6S/c1-10-16(31-21(29)30-10)9-23-3-5-24(6-4-23)15-8-14-12(7-13(15)22)18(26)17(20(27)28)19-25(14)11(2)32-19/h7-8,11H,3-6,9H2,1-2H3,(H,27,28)
• InChIKey: PWNMXPDKBYZCOO-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 6-fluoro-1-methyl-7-{4-[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl]piperazin-1-yl}-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
• IUPAC Traditional name: 6-fluoro-1-methyl-7-{4-[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl]piperazin-1-yl}-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid; prulifloxacin
• Synonyms: 6-Fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo-1H,4H-[1,3]Thiazeto[3,2-a]quinoline-3-carboxylic Acid; NM 441; Quisnon; Sword; Prulifloxacin; Prulifloxacin; 6-fluoro-1-methyl-7-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxo-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid

Database IDs

• CAS Number: 5875-06-9; 123447-62-1
• PubChem SID: 162219333
• PubChem CID: 65947

CALCULATED PROPERTIES

• Acid pKa: 5.9755955
• H Acceptors: 8
• H Donor: 1
• LogD (pH = 5.5): 2.6894138
• LogD (pH = 7.4): 1.428254
• Log P: 2.6541631
• Molar Refractivity: 127.3688 cm^3
• Polarizability: 43.320644 Å^3
• Polar Surface Area: 99.62 Å^2
• Rotatable Bonds: 4
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: DMSO
• Apperance: Off-White Solid
• Melting Point: 211-214°C

Safety Information

• Storage Condition: -20°C Freezer

Pharmacology Properties

• Mechanism of Action: Blocker of bacterial DNA replication; Interference with DNA gyrase (supercoiling; reestablishment of DNA coil integrity during replication)

Product Information

• Application(s): Antibacterial agent; Antiseptic; Prodrug

DETAILS

Toronto Research Chemicals - P838885

Prulifloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. Prulifloxacin is a prodrug for active metabolite, Ulifloxacin. Antibacterial.

REFERENCES

• Ozaki, M., et al.: Antimicrob. Agents Chemother., 35, 2496 (1991)
• Segawa, J., et al.: J. Med. Chem., 35, 4727 (1991)
• Nakashima, M., et al.: J. Clin. Pharmacol., 34, 930 (1991)
• Eur. Pat., 1989, Nippon Shinyaku, 315 828; CA, 111, 194791, (synth, pharmacol)
• Ozaki, M. et al., Antimicrob. Agents Chemother., 1991, 35, 2496; 1992, 36, 1170; 1993, 37, 930
• Segawa, J. et al., J. Med. Chem., 1992, 35, 4727, (synth, pmr, ir, pharmacol)
• Nakashima, M. et al., J. Clin. Pharmacol., 1994, 34, 930, (pharmacokinet, man)