Ivermectin

• Catalog No.: Bio-0055
• CAS Number: 70288-86-7
• M. F.: C48H74O14
• M. W.: 875.09276

SYNONYMS

• IUPAC name: (1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-{[(4S,5S,6S)-5-{[(4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1^4,^8.0^2^0,^2^4]pentacosane]-10',14',16',22'-tetraen-2'-one
• IUPAC Traditional name: (1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-{[(4S,5S,6S)-5-{[(4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1^4,^8.0^2^0,^2^4]pentacosane]-10',14',16',22'-tetraen-2'-one
• Synonyms: Mectizan; Ivomec; Eqvalan; Oramec; Hyvermectin

DATABASE IDS

• CAS Number: 70288-86-7

PROPERTIES

• Application(s): Broad spectrum antiparasitic agent
• Application(s): Used in elimination programme for African onchocerciasis (river blindness)
• Mechanism of Action: Neurotransmission inhibitor in parasites

REFERENCES

• Chabala, J.C. et al., J. Med. Chem., 1980, 23, 1134, (synth, props)
• U.S. Pat., 1980, 4 199 569; CA, 93, 130559, (synth)
• Campbell, W.C. et al., Science (Washington, D.C.), 1983, 221, 823, (rev, pharmacol)
• Calcott, P.H. et al., J. Antibiot., 1984, 37, 253, (props)
• Koch, H., Pharm. Int., 1984, 5, 55, (rev)
• Fink, D.W., Anal. Profiles Drug Subst., 1988, 17, 155, (rev)
• Baker, R. et al., Chem. Ber., 1989, 25, 692, (rev)
• Campbell, W.C., Annu. Rev. Microbiol., 1991, 45, 445, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 43
• Campbell, W.C., Med. Res. Rev., 1993, 13, 61, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, ITD875