(1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-{[(4S,5S,6S)-5-{[(4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one

• ChemBase ID: 179699
• Molecular Formular: C48H74O14
• Molecular Mass: 875.09276
• Monoisotopic Mass: 874.50785705
• SMILES: [C@@H]12[C@]3([C@H](OC/C/3=C\C=C\[C@@H]([C@@H](/C(=C/C[C@H]3O[C@]4(O[C@@H]([C@H](CC4)C)[C@H](CC)C)C[C@@H](OC1=O)C3)/C)OC1O[C@H]([C@@H]([C@H](C1)OC)OC1O[C@H]([C@@H]([C@H](C1)OC)O)C)C)C)[C@@H](C(=C2)C)O)O
• Canonical SMILES: CO[C@H]1CC(O[C@H]2[C@@H](C)/C=C/C=C/3\CO[C@H]4[C@]3(O)[C@@H](C=C([C@H]4O)C)C(=O)O[C@H]3C[C@@H](C/C=C/2\C)O[C@]2(C3)CC[C@@H]([C@H](O2)[C@H](CC)C)C)O[C@H]([C@@H]1OC1C[C@H](OC)[C@H]([C@@H](O1)C)O)C
• InChI: InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33?,34-,35-,36-,37-,38?,39?,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
• InChIKey: AZSNMRSAGSSBNP-IJFRUGBASA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-{[(4S,5S,6S)-5-{[(4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1^4,^8.0^2^0,^2^4]pentacosane]-10',14',16',22'-tetraen-2'-one
• IUPAC Traditional name: (1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-6-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-{[(4S,5S,6S)-5-{[(4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1^4,^8.0^2^0,^2^4]pentacosane]-10',14',16',22'-tetraen-2'-one
• Synonyms: Eqvalan; Hyvermectin; Ivomec; Mectizan; Oramec; Ivermectin

Database IDs

• CAS Number: 70288-86-7
• PubChem SID: 164235609
• PubChem CID: 42648499

CALCULATED PROPERTIES

• Acid pKa: 12.467905
• H Acceptors: 13
• H Donor: 3
• LogD (pH = 5.5): 5.8257456
• LogD (pH = 7.4): 5.825742
• Log P: 5.8257456
• Molar Refractivity: 230.3276 cm^3
• Polarizability: 92.01296 Å^3
• Polar Surface Area: 170.06 Å^2
• Rotatable Bonds: 8
• Lipinski's Rule of Five: false

PROPERTIES

Pharmacology Properties

• Mechanism of Action: Neurotransmission inhibitor in parasites

Product Information

• Application(s): Broad spectrum antiparasitic agent; Used in elimination programme for African onchocerciasis (river blindness)

REFERENCES

• Chabala, J.C. et al., J. Med. Chem., 1980, 23, 1134, (synth, props)
• U.S. Pat., 1980, 4 199 569; CA, 93, 130559, (synth)
• Campbell, W.C. et al., Science (Washington, D.C.), 1983, 221, 823, (rev, pharmacol)
• Calcott, P.H. et al., J. Antibiot., 1984, 37, 253, (props)
• Koch, H., Pharm. Int., 1984, 5, 55, (rev)
• Fink, D.W., Anal. Profiles Drug Subst., 1988, 17, 155, (rev)
• Baker, R. et al., Chem. Ber., 1989, 25, 692, (rev)
• Campbell, W.C., Annu. Rev. Microbiol., 1991, 45, 445, (rev)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 43
• Campbell, W.C., Med. Res. Rev., 1993, 13, 61, (rev)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, ITD875