NAMES AND DATABASE IDS
NAMES AND DATABASE IDS
Names Database IDs
IUPAC name
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3,4,10,11-tetramethoxy-7,8-dihydro-6$l^{5}-azatetraphen-6-ylium chloride
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3,4,10,11-tetramethoxy-7,8-dihydro-6λ5-azatetraphen-6-ylium chloride
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IUPAC Traditional name
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Synonyms
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Palmatine hydrochloride
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Palmatine chloride
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2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium chloride
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CAS Number
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PubChem SID
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PubChem CID
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DATA SOURCES
DATA SOURCES
All Sources Commercial Sources Non-commercial Sources
CALCULATED PROPERTIES
CALCULATED PROPERTIES
JChem
H Acceptors
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4
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H Donor
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0
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LogD (pH = 5.5)
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-1.2218883
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LogD (pH = 7.4)
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-1.2218883
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Log P
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-1.2218883
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Molar Refractivity
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100.6828 cm3
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Polarizability
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41.039276 Å3
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Polar Surface Area
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40.8 Å2
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Rotatable Bonds
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4
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Lipinski's Rule of Five
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true
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DETAILS
DETAILS
Selleck Chemicals
Selleck Chemicals -
S2397
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Research Area: Neurological Disease Biological Activity: Palmatine hydrochloride (Palmatine chloride (6CI,7CI)) is a hydrochloride salt of palmatine which is a protoberberine alkaloid. Palmatine hydrochloride (Palmatine chloride (6CI,7CI)) has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases. [1] Palmatine inhibited carbachol-induced Ca2+-activated Cl− secretion and the carbachol-induced increase of intracellular Ca2+ concentration. Palmatine also inhibited cAMP-activated Cl− secretion induced by prostaglandin E2 (PGE2) or forskolin. Palmatine prevented the elevation of intracellular cAMP by forskolin. Determination of apical Cl− currents showed that palmatine suppressed the forskolin-stimulated, apical cAMP-activated Cl− current but not the carbachol-stimulated apical Ca2+-activated Cl− current. [2] |
PATENTS
PATENTS
PubChem Patent
Google Patent