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Palmatine chloride

Catalog No. S2397 Name Selleck Chemicals
CAS Number 10605-02-4 Website http://www.selleckchem.com
M. F. C21H22ClNO4 Telephone (877) 796-6397
M. W. 387.85668 Fax (832) 582-8590
Purity Email sales@selleckchem.com
Storage -20°C Chembase ID: 73017


IUPAC name
3,4,10,11-tetramethoxy-7,8-dihydro-6$l^{5}-azatetraphen-6-ylium chloride
IUPAC Traditional name
palmatine chloride
Palmatine hydrochloride


CAS Number 10605-02-4


Salt Data chloride
Storage Condition -20°C


Description (English)
Research Area: Neurological Disease
Biological Activity:
Palmatine hydrochloride (Palmatine chloride (6CI,7CI)) is a hydrochloride salt of palmatine which is a protoberberine alkaloid. Palmatine hydrochloride (Palmatine chloride (6CI,7CI)) has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases. [1] Palmatine inhibited carbachol-induced Ca2+-activated Cl− secretion and the carbachol-induced increase of intracellular Ca2+ concentration. Palmatine also inhibited cAMP-activated Cl− secretion induced by prostaglandin E2 (PGE2) or forskolin. Palmatine prevented the elevation of intracellular cAMP by forskolin. Determination of apical Cl− currents showed that palmatine suppressed the forskolin-stimulated, apical cAMP-activated Cl− current but not the carbachol-stimulated apical Ca2+-activated Cl− current. [2]


  • Wu DZ et al. Br J Pharmacol. 2008 Mar;153(6):1203-13.