3-ethyl 5-methyl (4S)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

• ChemBase ID: 168875
• Molecular Formular: C18H19Cl2NO4
• Molecular Mass: 384.25376
• Monoisotopic Mass: 383.06911345
• SMILES: N1C(=C([C@@H](C(=C1C)C(=O)OCC)c1cccc(c1Cl)Cl)C(=O)OC)C
• Canonical SMILES: CCOC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1Cl)Cl)C(=O)OC)C
• InChI: InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3/t15-/m0/s1
• InChIKey: RZTAMFZIAATZDJ-HNNXBMFYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: 3-ethyl 5-methyl (4S)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• IUPAC Traditional name: 3-ethyl 5-methyl (4S)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: (4R)-4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester; (+)-Felodipine; (R)-Felodipine; (R)-(+)-Felodipine; Agon; Feloc; Fensel; Hydac; Modip; Plandil; Plendil; Splendil; Felodipine

Database IDs

• CAS Number: 72509-76-3; 119945-59-4
• PubChem SID: 162263007
• PubChem CID: 941699

CALCULATED PROPERTIES

• H Acceptors: 3
• H Donor: 1
• LogD (pH = 5.5): 3.1918502
• LogD (pH = 7.4): 3.436203
• Log P: 3.4404075
• Molar Refractivity: 99.1982 cm^3
• Polarizability: 37.720104 Å^3
• Polar Surface Area: 64.63 Å^2
• Rotatable Bonds: 6
• Lipinski's Rule of Five: true

PROPERTIES

Pharmacology Properties

• Mechanism of Action: Blocks voltage-dependent calcium currents in vascular smooth muscle and cultured rabbit atrial cells, and blocks potassium-induced contracture of the rat portal vein; By blocking the calcium channels, inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes and; Calcium channel blocker; results in a decrease of peripheral vascular resistance.; Reversibly competes with nitrendipine and other calcium channel blockers for dihydropyridine binding sites

Product Information

• Application(s): Antihypertensive agent; Used to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina; Vasodilator

DETAILS

Toronto Research Chemicals - F232365

A dihydropyridine calcium channel blocker. Enantiomer R of Felodipine.

REFERENCES

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