(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine tetrahydrochloride

• ChemBase ID: 102176
• Molecular Formular: C10H30Cl4N4
• Molecular Mass: 348.184
• Monoisotopic Mass: 346.1224577
• SMILES: Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
• Canonical SMILES: NCCCNCCCCNCCCN.Cl.Cl.Cl.Cl
• InChI: InChI=1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• InChIKey: XLDKUDAXZWHPFH-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• IUPAC name: (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine tetrahydrochloride
• IUPAC Traditional name: spermine tetrahydrochloride
• Synonyms: Spermine tetrahydrochloride; Additive Screening Solution 31/Fluka kit no 78374; Spermine tetrahydrochloride solution; Spermine tetrahydrochloride 0.1 M solution; N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride; N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride; Geontine Tetrahydrochloride; SPERMINE TETRAHYDROCHLORIDE; N,N′-双(3-氨丙基)-1,4-丁二胺 四盐酸盐; 精胺 四盐酸盐

Database IDs

• CAS Number: 306-67-2
• EC Number: 206-189-8
• MDL Number: MFCD00012914
• Beilstein Number: 3911771
• PubChem SID: 24888397; 162088638; 24278007; 24899462
• PubChem CID: 9384

CALCULATED PROPERTIES

• H Acceptors: 4
• H Donor: 4
• LogD (pH = 5.5): -13.23318
• LogD (pH = 7.4): -9.554461
• Log P: -1.4540076
• Molar Refractivity: 62.5582 cm^3
• Polarizability: 25.284222 Å^3
• Polar Surface Area: 76.1 Å^2
• Rotatable Bonds: 11
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: H2O: soluble1 m at 20 °C, clear, colorless to almost colorless
• Apperance: powder
• Melting Point: 310-311 °C (dec.)(lit.); 312-314°C
• Density: 1.01 g/mL at 20 °C
• Absorption Wavelength: λ: 260 nm Amax: 0.2; λ: 280 nm Amax: 0.15
• pH: 4.5-7.0 (25 °C, 1 M in H2O)

Safety Information

• Storage Condition: 0°C, Desiccate
• RTECS: EJ7230000
• European Hazard Symbols: Irritant (Xi)
• German water hazard class: 3
• Risk Statements: 36/38
• Safety Statements: 26-36
• GHS Pictograms: GHS07
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319
• GHS Precautionary statements: P305 + P351 + P338
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves; Eyeshields, Gloves
• Storage Temperature: 2-8°C; room temp

Pharmacology Properties

• Gene Information: human ... GRIN1(2902)

Product Information

• Purity: ≥99.5% (AT); 96-98%
• Grade: for molecular biology
• Impurities: DNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected; RNases, none detected
• Cation Traces: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• Antion Traces: sulfate (SO42-): ≤50 mg/kg
• Foreign Activity: DNase, RNase, protease, NICKase, none detected
• Quality Level: PREMIUM
• λ: 1 M in H2O
• Product Line: BioUltra
• Empirical Formula (Hill Notation): C10H26N4 · 4HCl

DETAILS

MP Biomedicals - 02100474

Tetrahydrochloride
Crystalline
Purity: 96-98%

Sigma Aldrich - 85605

Application
Used to precipitate DNA from low salt aqueous buffers.1
Other Notes
Spermine precipitation of DNA1
Biochem/physiol Actions
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Sigma Aldrich - S1141

Application
用于从低盐缓冲液中沉淀 DNA。1
Biochem/physiol Actions
多胺位点混合型 NMDA 激动-拮抗剂。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。
多胺位点混合型 NMDA 激动-拮抗剂。在高浓度 (1mM) 下观察到神经保护作用，而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。

Sigma Aldrich - S2876

Application
用于从低盐缓冲液中沉淀 DNA。1
Biochem/physiol Actions
多胺位点混合型 NMDA 激动-拮抗剂。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。
多胺位点混合型 NMDA 激动-拮抗剂。在高浓度 (1mM) 下观察到神经保护作用，而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。