Spermine tetrahydrochloride

• Catalog No.: 85605
• CAS Number: 306-67-2
• M. F.: C10H30Cl4N4
• M. W.: 348.184
• Purity: ≥99.5% (AT)

SYNONYMS

• Title: 精胺 四盐酸盐
• IUPAC name: (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine tetrahydrochloride
• IUPAC Traditional name: spermine tetrahydrochloride
• Synonyms: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride; N,N′-双(3-氨丙基)-1,4-丁二胺 四盐酸盐

DATABASE IDS

• PubChem SID: 24888397
• MDL Number: MFCD00012914
• CAS Number: 306-67-2
• Beilstein Number: 3911771
• EC Number: 206-189-8

PROPERTIES

• Antion Traces: sulfate (SO42-): ≤50 mg/kg
• Cation Traces: Al: ≤5 mg/kg
• Cation Traces: As: ≤0.1 mg/kg
• Cation Traces: Ba: ≤5 mg/kg
• Cation Traces: Bi: ≤5 mg/kg
• Cation Traces: Ca: ≤10 mg/kg
• Cation Traces: Cd: ≤5 mg/kg
• Cation Traces: Co: ≤5 mg/kg
• Cation Traces: Cr: ≤5 mg/kg
• Cation Traces: Cu: ≤5 mg/kg
• Cation Traces: Fe: ≤5 mg/kg
• Cation Traces: K: ≤50 mg/kg
• Cation Traces: Li: ≤5 mg/kg
• Cation Traces: Mg: ≤5 mg/kg
• Cation Traces: Mn: ≤5 mg/kg
• Cation Traces: Mo: ≤5 mg/kg
• Cation Traces: Na: ≤50 mg/kg
• Cation Traces: Ni: ≤5 mg/kg
• Cation Traces: Pb: ≤5 mg/kg
• Cation Traces: Sr: ≤5 mg/kg
• Cation Traces: Zn: ≤5 mg/kg
• Empirical Formula (Hill Notation): C10H26N4 · 4HCl
• Grade: for molecular biology
• Impurities: DNases, none detected
• Impurities: RNases, none detected
• Impurities: insoluble matter, passes filter test
• Impurities: phosphatases, none detected
• Impurities: proteases, none detected
• λ: 1 M in H2O
• Product Line: BioUltra
• Purity: ≥99.5% (AT)
• Quality Level: PREMIUM
• Absorption Wavelength: λ: 260 nm Amax: 0.2
• Absorption Wavelength: λ: 280 nm Amax: 0.15
• Melting Point: 310-311 °C (dec.)(lit.)
• pH: 4.5-7.0 (25 °C, 1 M in H2O)
• Solubility: H2O: soluble1 m at 20 °C, clear, colorless to almost colorless
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319
• European Hazard Symbols: Irritant (Xi)
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves
• GHS Precautionary statements: P305 + P351 + P338
• Risk Statements: 36/38
• RTECS: EJ7230000
• Safety Statements: 26-36
• German water hazard class: 3

DETAILS

Description (English)

Application
Used to precipitate DNA from low salt aqueous buffers.1
Other Notes
Spermine precipitation of DNA1
Biochem/physiol Actions
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Description (简体中文)

Application
用于从低盐缓冲液中沉淀 DNA。1
Other Notes
Spermine precipitation of DNA1
Biochem/physiol Actions
多胺位点混合型 NMDA 激动-拮抗剂。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。
多胺位点混合型 NMDA 激动-拮抗剂。在高浓度 (1mM) 下观察到神经保护作用，而在低浓度下则观察到神经毒性。它在番木鳖碱-不敏感性甘氨酸位点能够增强激动剂效应。在细胞增殖和分化中发挥作用；抑制神经元一氧化氮合成酶 (nNOS)。