Fluvastatin Sodium

• Catalog No.: S1909
• CAS Number: 93957-55-2
• M. F.: C24H25FNNaO4
• M. W.: 433.4477732
• Storage: -20°C

SYNONYMS

• IUPAC name: sodium (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate
• IUPAC Traditional name: sodium (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropylindol-2-yl]-3,5-dihydroxyhept-6-enoate
• Synonyms: Vastin; Lescol; XU 62-320; Canef

DATABASE IDS

• CAS Number: 93957-55-2

PROPERTIES

• Salt Data: Sodium
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Cardiovascular Disease
Biological Activity:
Fluvastatin sodium (Lescol) is an orally active, potent and competitive HMG-CoA reductase inhibitor with an IC50 of 70 nM for vascular smooth muscle proliferation in vitro. (IC50 = 40 -100 nM at human liver microsomes). It exhibits antihyperchole-sterolemic and antioxidant activity in vivo. Fluvastatin Sodium is used to reduce LDL-cholesterol, apolipoprotein B, and triglycerides, and to increase HDL-cholesterol, in the treatment of hyperlipidaemias, including hypercholesterolaemias and combined (mixed) hyperlipidaemia (type IIa or IIb hyperlipoproteinaemias). [1]

REFERENCES

• http://en.wikipedia.org/wiki/Fluvastatin