Genistein

• Catalog No.: S1342
• CAS Number: 446-72-0
• M. F.: C15H10O5
• M. W.: 270.2369
• Storage: -20°C

SYNONYMS

• IUPAC name: 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
• IUPAC Traditional name: genistein

DATABASE IDS

• CAS Number: 446-72-0

PROPERTIES

• Target: EGFR EGFR
• Salt Data: Free Base
• Solubility: DMSO
• Storage Condition: -20°C

DETAILS

Description (English)

Research Area: Prostate cancer
Biological Activity:
Genistein is a soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. [1]

REFERENCES

• http://www.cancer.gov/drugdictionary/?CdrID=43214