Tetramethylammonium chloride

• Catalog No.: A13288
• CAS Number: 75-57-0
• M. F.: C4H12ClN
• M. W.: 109.59778
• Purity: 97%, may cont. ca 3% silica as anticaking agent

SYNONYMS

• Title: 四甲基氯化铵
• IUPAC name: tetramethylazanium chloride
• IUPAC Traditional name: tetramethylammonium chloride

DATABASE IDS

• Beilstein Number: 2496575
• MDL Number: MFCD00011628
• CAS Number: 75-57-0
• EC Number: 200-880-8

PROPERTIES

• Purity: 97%, may cont. ca 3% silica as anticaking agent
• Density: 1.17
• Melting Point: >300°C
• GHS Hazard statements: H301-H311-H315-H319-H335
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P280H-P305+P351+P338-P309-P310
• Risk Statements: 21-25-36/37/38
• RTECS: BS7700000
• Safety Statements: 26-36/37-45
• Storage Warning: Hygroscopic
• TSCA Listed: 是
• Hazard Class: 6.1
• UN Number: UN2811
• Packing Group: II

REFERENCES

• Thermally-stable phase-transfer catalyst (see Appendix 2) which has been used in nucleophilic displacement reactions of aryl nitro groups with KF in tetramethylene sulfone: J. Org. Chem., 56, 6406 (1991). A detailed study of the halex Cl ^- /F ^- exchange reaction of activated aryl chlorides, for example the conversion of 1,2-dichloro-4-nitrobenzene to 2-chloro-1-fluoro-4-nitrobenzene in DMSO at 120^oC showed tetramethylammonium chloride to be superior to other common phase-transfer catalysts. It was necessary to pre-dry the catalyst to <0.2% water to avoid competition from hydrolytic displacement: Chem. Commun., 297 (1996).
• Compare also Tetraphenylphosphonium bromide, A15860 and Tetraphenylphosphonium chloride, A10575.