tetramethylazanium chloride

• ChemBase ID: 77906
• Molecular Formular: C4H12ClN
• Molecular Mass: 109.59778
• Monoisotopic Mass: 109.06582707
• SMILES: [N+](C)(C)(C)C.[Cl-]
• Canonical SMILES: C[N+](C)(C)C.[Cl-]
• InChI: InChI=1S/C4H12N.ClH/c1-5(2,3)4;/h1-4H3;1H/q+1;/p-1
• InChIKey: OKIZCWYLBDKLSU-UHFFFAOYSA-M

NAMES AND DATABASE IDS

Names

• IUPAC name: tetramethylazanium chloride
• IUPAC Traditional name: tetramethylammonium ion chloride; tetramethylammonium chloride
• Synonyms: TMA; Tetramethylammonium chloride; Tetramethylammonium chloride solution; Tetramethylammonium chloride; Tetramethylammonium chloride; N,N,N-Trimethyl methanaminium chloride; Tetramine chloride; USAF AN-8; 四甲基氯化铵; 四甲基氯化铵 溶液

Database IDs

• CAS Number: 75-57-0
• EC Number: 200-880-8
• MDL Number: MFCD00011628
• Beilstein Number: 2496575; 3911201
• PubChem SID: 24886658; 24888936; 24900143; 24888937; 24900000; 162042749
• PubChem CID: 6379
• Wikipedia Title: Tetramethylammonium_chloride

CALCULATED PROPERTIES

• H Acceptors: 0
• H Donor: 0
• LogD (pH = 5.5): -3.9721673
• LogD (pH = 7.4): -3.9721673
• Log P: -3.9721673
• Molar Refractivity: 35.9017 cm^3
• Polarizability: 9.572162 Å^3
• Polar Surface Area: 0.0 Å^2
• Rotatable Bonds: 0
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: H2O: soluble6 M at 20 °C, clear, colorless; methanol: soluble0.1 g/mL, clear, colorless; Soluble in water
• Apperance: White crystals
• Melting Point: > 300°C; >300 °C(lit.); >300°C; >300°C; 425 °C (dec)
• Density: 1.169; 1.17; 1.17 g/cm^3; 1.17 g/ml
• Absorption Wavelength: λ: 220 nm Amax: 0.05; λ: 230 nm Amax: 0.04; λ: 250 nm Amax: 0.03; λ: 260 nm Amax: 0.02; λ: 280 nm Amax: 0.02; λ: 500 nm Amax: 0.02

Safety Information

• Storage Condition: Room Temperature (15-30°C), Desiccate
• Storage Warning: Hygroscopic; Toxic/Harmful/Irritant/Hygroscopic/Store under Argon
• RTECS: BS7700000
• European Hazard Symbols: Toxic (T); Irritant (Xi)
• UN Number: 2810; 2811; UN2811
• German water hazard class: 1
• Hazard Class: 6.1
• Packing Group: 2; 3; II
• Australian Hazchem: 2XE
• Risk Statements: 21-25-36/37/38; R:25-36/37/38
• Safety Statements: 26-28-36/37-45; 26-36/37-45; S:20-26-46-36/37/39
• EU Classification: T2
• EU Hazard Identification Number: 6.1B
• Emergency Response Guidebook(ERG) Number: 154
• TSCA Listed: 是
• GHS Pictograms: GHS06
• GHS Signal Word: Danger
• GHS Hazard statements: H300-H311-H315-H319-H335; H301 + H311-H315-H319-H335; H301-H311-H315-H319-H335
• GHS Precautionary statements: P261-P264-P280-P301 + P310-P305 + P351 + P338-P312; P261-P280-P301 + P310-P305 + P351 + P338-P312; P280H-P305+P351+P338-P309-P310
• Personal Protective Equipment: Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter; Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• RID/ADR: UN 2810 6.1/PG 3; UN 2811 6.1/PG 2

Product Information

• Purity: ~98%; ≥98%; ≥98.0% (AT); ≥99.0%; ≥99.0% (AT); 95+%; 97%, may cont. ca 3% silica as anticaking agent
• Concentration: 5 M
• Grade: for electrochemical analysis; for ion pair chromatography; for molecular biology; purum; reagent grade
• Suitability: corresponds to standard for filter test; corresponds to standard for RP gradient test
• Impurities: ≤2% water; DNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected; RNases, none detected
• Cation Traces: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• Antion Traces: bromide (Br-): ≤500 mg/kg; sulfate (SO42-): ≤50 mg/kg
• Foreign Activity: DNase, RNase, none detected
• λ: 1 M in H2O; 10 % in H2O
• Product Line: BioUltra
• Linear Formula: (CH3)4N(Cl)

DETAILS

MP Biomedicals - 02152113

Crystalline
Purity: ~98%

Sigma Aldrich - T3411

Application
四甲基铵结合富含 AT 的 DNA 聚合物，进而避免 AT 相对 GC 碱基对的优先熔解。以 18 兆欧水中 0.2μm 过滤溶液形式提供。

Sigma Aldrich - 87718

Other Notes
Hybridization of genomic DNA to AT-rich oligonucleotide probes1

Sigma Aldrich - 87719

General description
Visit our Sensor Applications portal to learn more.

Sigma Aldrich - T19526

Packaging
100, 500 g in poly bottle
5 g in glass bottle

REFERENCES

• Thermally-stable phase-transfer catalyst (see Appendix 2) which has been used in nucleophilic displacement reactions of aryl nitro groups with KF in tetramethylene sulfone: J. Org. Chem., 56, 6406 (1991). A detailed study of the halex Cl ^- /F ^- exchange reaction of activated aryl chlorides, for example the conversion of 1,2-dichloro-4-nitrobenzene to 2-chloro-1-fluoro-4-nitrobenzene in DMSO at 120^oC showed tetramethylammonium chloride to be superior to other common phase-transfer catalysts. It was necessary to pre-dry the catalyst to <0.2% water to avoid competition from hydrolytic displacement: Chem. Commun., 297 (1996).
• Compare also Tetraphenylphosphonium bromide, A15860 and Tetraphenylphosphonium chloride, A10575.