Lithium chloride, anhydrous

• Catalog No.: A10531
• CAS Number: 7447-41-8
• M. F.: ClLi
• M. W.: 42.394
• Purity: 98+%

SYNONYMS

• Title: 无水氯化锂
• IUPAC name: lithium(1+) ion chloride
• IUPAC Traditional name: lithium(1+) ion chloride

DATABASE IDS

• EC Number: 231-212-3
• CAS Number: 7447-41-8
• MDL Number: MFCD00011078
• Merck Index: 145528

PROPERTIES

• Purity: 98+%
• Boiling Point: 1325-1360°C
• Density: 2.068
• Melting Point: 605°C
• GHS Hazard statements: H301-H315-H319-H335
• European Hazard Symbols: X
• GHS Precautionary statements: P261-P301+P310-P305+P351+P338-P302+P352-P405-P501A
• Risk Statements: 22-36/37/38
• RTECS: OJ5950000
• Safety Statements: 26-36/37
• Storage Warning: Hygroscopic
• TSCA Listed: 是

REFERENCES

• In DMF, acts as a base in dehydrohalogenation reactions; see, for example: Org. Synth. Coll., 4, 162 (1963). See also lithium carbonate (preceding entry). A comparison has been made of its activity with or without microwave irradiation for promoting the Knoevenagel condensation in N-methylpyrrolidinone, e.g. of malononitrile: Chem. Commun., 773 (1998).
• For use in the dealkylation of activated aralkyl ethers, see: Synthesis, 287 (1989).
• In the Wadsworth-Emmons olefination reaction, Triethylamine, A12646, was effective as base in combination a number of metal salts of which Li halides gave the highest yields: J. Org. Chem., 50, 2624 (1985).
• Additive in the Stille coupling reaction of alkyl and arylstannanes with aryl triflates, preventing decomposition of the palladium complex catalyst: J. Am. Chem. Soc., 106, 4630 (1984); 108, 3033 (1986); see also Tri-n-butyltin chloride, A10746.
• The combination of LiCl and water in DMSO provides a mild and efficient method for deprotection of THP ethers: J. Org. Chem., 61, 6038 (1996), and ethylene acetals: Tetrahedron Lett., 38, 7271 (1997).