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Minaprine

Catalog No. DB00805 Name DrugBank
CAS Number 25905-77-5 Website http://www.ualberta.ca/
M. F. C17H22N4O Telephone (780) 492-3111
M. W. 298.38278 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 684

SYNONYMS

IUPAC name
4-methyl-N-[2-(morpholin-4-yl)ethyl]-6-phenylpyridazin-3-amine
IUPAC Traditional name
minaprine
Brand Name
Brantur
Cantor
Synonyms
Minaprinum [INN-Latin]
Minaprine Hydrochloride
Minaprina [INN-Spanish]
Minaprine Dihydrochloride

DATABASE IDS

PubChem CID 4199
PubChem SID 46505380
CAS Number 25905-77-5

PROPERTIES

Hydrophobicity(logP) 2
Solubility 2360 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
Indication For the treatment of depression
Pharmacology Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain. Similar to other antidepressant treatments, minaprine attenuates the beta-adrenergic receptor function. Studies have also shown that minaprine improves memory consolidation and that repeated drug administration leads to potentiation of this effect. Moreover, the effects of minaprine on memory consolidation are related to its dopaminergic action.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic. Cytochrome P4502D is responsible for the 4-hydroxylation of minaprine to 4-hydroxyminaprine.

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