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25905-77-5 molecular structure
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4-methyl-N-[2-(morpholin-4-yl)ethyl]-6-phenylpyridazin-3-amine

ChemBase ID: 684
Molecular Formular: C17H22N4O
Molecular Mass: 298.38278
Monoisotopic Mass: 298.17936134
SMILES and InChIs

SMILES:
O1CCN(CC1)CCNc1nnc(cc1C)c1ccccc1
Canonical SMILES:
Cc1cc(nnc1NCCN1CCOCC1)c1ccccc1
InChI:
InChI=1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20)
InChIKey:
LDMWSLGGVTVJPG-UHFFFAOYSA-N

Cite this record

CBID:684 http://www.chembase.cn/molecule-684.html

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NAMES AND DATABASE IDS

NAMES AND DATABASE IDS

Names Database IDs
IUPAC name
4-methyl-N-[2-(morpholin-4-yl)ethyl]-6-phenylpyridazin-3-amine
IUPAC Traditional name
minaprine
Brand Name
Brantur
Cantor
Synonyms
Minaprine Hydrochloride
Minaprine Dihydrochloride
Minaprina [INN-Spanish]
Minaprinum [INN-Latin]
Minaprine
CAS Number
25905-77-5
PubChem SID
46505380
160964147
PubChem CID
4199
ATC CODE
N06AX07
CHEMBL
278819
Chemspider ID
4054
KEGG ID
D05039
Unique Ingredient Identifier
00U7GX0NLM
Wikipedia Title
Minaprine

DATA SOURCES

DATA SOURCES

All Sources Commercial Sources Non-commercial Sources
Data Source Data ID Price

CALCULATED PROPERTIES

CALCULATED PROPERTIES

JChem ALOGPS 2.1
Acid pKa 19.25459  H Acceptors
H Donor LogD (pH = 5.5) 1.3438344 
LogD (pH = 7.4) 2.1580982  Log P 2.1896803 
Molar Refractivity 91.1707 cm3 Polarizability 34.957195 Å3
Polar Surface Area 50.28 Å2 Rotatable Bonds
Lipinski's Rule of Five true 
Log P 2.15  LOG S -3.63 
Solubility (Water) 7.01e-02 g/l 

PROPERTIES

PROPERTIES

Physical Property Pharmacology Properties Bioassay(PubChem)
Solubility
2360 mg/L expand Show data source
Hydrophobicity(logP)
2 expand Show data source
Admin Routes
Oral expand Show data source
Half Life
2-2.5 hours expand Show data source
Legal Status
Rx-only expand Show data source

DETAILS

DETAILS

DrugBank DrugBank Wikipedia Wikipedia
DrugBank - DB00805 external link
Item Information
Drug Groups approved
Description Minaprine is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.
Indication For the treatment of depression
Pharmacology Minaprine is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain. Similar to other antidepressant treatments, minaprine attenuates the beta-adrenergic receptor function. Studies have also shown that minaprine improves memory consolidation and that repeated drug administration leads to potentiation of this effect. Moreover, the effects of minaprine on memory consolidation are related to its dopaminergic action.
Affected Organisms
Humans and other mammals
Biotransformation Hepatic. Cytochrome P4502D is responsible for the 4-hydroxylation of minaprine to 4-hydroxyminaprine.

REFERENCES

REFERENCES

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PATENTS

PATENTS

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INTERNET

INTERNET

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