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Magnesium Sulfate

Catalog No. DB00653 Name DrugBank
CAS Number 7487-88-9 Website http://www.ualberta.ca/
M. F. MgO4S Telephone (780) 492-3111
M. W. 120.3676 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 535

SYNONYMS

IUPAC name
magnesium(2+) ion sulfate
IUPAC Traditional name
magnesium(2+) sulfate
Brand Name
Elliotts B Solution
Sal anglicum
Hair salt
Kieserite [as monohydrate]
Epsom salts
Sal amarum
Sal catharticum
Sal seidlitense
Salts of England
Sel d'angleterre
Synonyms
Magnesium sulfate heptahydrate
Magnesium Sulphate Heptahydrate
Bitter salt
Magnesium sulfate anhydrous
Magnesium sulfate dried
Magnesium sulphate
Magnesium Sulphate Hydrate

DATABASE IDS

CAS Number 7487-88-9
PubChem CID 24083
PubChem SID 46508411

PROPERTIES

Hydrophobicity(logP) -0.91
Solubility 710 mg/mL

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
Indication Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
Pharmacology Magnesium sulfate is a small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. Magnesium sulfate is gaining popularity as an initial treatment in the management of various dysrhythmias, particularly torsades de pointes, and dyrhythmias secondary to TCA overdose or digitalis toxicity.
Toxicity LD50 = 1200 mg/kg (rat, subcutaneous). May be harmful if swallowed. May act as an irritant. Adverse reactions include hypotension, ECG changes, diarrhea, urinary retention, CNS depression and respiratory depression.
Affected Organisms
Humans and other mammals
Biotransformation None
Half Life 43.2 hours (for newborns)
Protein Binding 25-30%
Elimination Magnesium is excreted solely by the kidney at a rate proportional to the serum concentration and glomerular filtration.
References
[Link]
Blitz M, Blitz S, Hughes R, Diner B, Beasley R, Knopp J, Rowe BH: Aerosolized magnesium sulfate for acute asthma: a systematic review. Chest. 2005 Jul;128(1):337-44. [Pubmed]
External Links
Wikipedia
RxList
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REFERENCES

  • Blitz M, Blitz S, Hughes R, Diner B, Beasley R, Knopp J, Rowe BH: Aerosolized magnesium sulfate for acute asthma: a systematic review. Chest. 2005 Jul;128(1):337-44. Pubmed
  • Link