magnesium(2+) ion sulfate

• ChemBase ID: 535
• Molecular Formular: MgO4S
• Molecular Mass: 120.3676
• Monoisotopic Mass: 119.93677118
• SMILES: [Mg+2].[O-]S(=O)(=O)[O-]
• Canonical SMILES: [O-]S(=O)(=O)[O-].[Mg+2]
• InChI: InChI=1S/Mg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
• InChIKey: CSNNHWWHGAXBCP-UHFFFAOYSA-L

NAMES AND DATABASE IDS

Names

• IUPAC name: magnesium(2+) ion sulfate
• IUPAC Traditional name: magnesium(2+) sulfate; magnesium(2+) ion sulfate
• Brand Name: Elliotts B Solution; Epsom salts; Hair salt; Kieserite [as monohydrate]; Sal amarum; Sal anglicum; Sal catharticum; Sal seidlitense; Salts of England; Sel d'angleterre
• Synonyms: Bitter salt; Magnesium sulfate anhydrous; Magnesium sulfate dried; Magnesium sulfate heptahydrate; Magnesium sulphate; Magnesium Sulphate Hydrate; Magnesium Sulphate Heptahydrate; Magnesium Sulfate; Sulfuric Acid Magnesium Salt (1:1); Epsom Salts; MAGNESIUM SULFATE ANHYDROUS; Magnesium sulfate, dried, contains ca 1-2 mol water of hydration; Magnesium sulfate, anhydrous; Magnesium sulfate solution; Magnesium sulfate; Epsom salt (heptahydrate); Bitter salts; Magnesium sulfate concentrate; Magnesium sulfate hydrate; Magnesium sulfate solution; ISA (ionic strength adjustment solution: 1 M MgSO4); Epsom salt; Magnesium sulfate heptahydrate; 硫酸镁, 干的, 含有大概 1-2 个结晶水; 无水硫酸镁; 硫酸镁 溶液; 硫酸镁; 硫酸镁 水合物; 硫酸镁 溶液; ISA（离子强度调节溶液：1M MgSO4）; 七水硫酸镁

Database IDs

• CAS Number: 10034-99-8; 7487-88-9; 22189-08-8
• EC Number: 231-298-2; 231-791-2; 231-104-6
• MDL Number: MFCD00149787; MFCD00149785; MFCD00011110
• Merck Index: 145691
• PubChem SID: 160963998; 24882418; 24852493; 24882414; 24848014; 24863818; 24852194; 24897227; 46508411; 24882401; 24896751; 24860732; 24896841; 24897165
• PubChem CID: 24083
• CHEBI ID: 32599
• ATC CODE: B05XA05; D11AX05; A06AD04; A12CC02; V04CC02
• CHEMBL: 1200456
• Chemspider ID: 22515
• DrugBank ID: DB00653
• Unique Ingredient Identifier: ML30MJ2U7I
• Wikipedia Title: Magnesium_sulfate

CALCULATED PROPERTIES

• Acid pKa: -3.034349
• H Acceptors: 4
• H Donor: 0
• LogD (pH = 5.5): -5.569452
• LogD (pH = 7.4): -5.594027
• Log P: -0.841552
• Molar Refractivity: 11.5274 cm^3
• Polarizability: 6.037845 Å^3
• Polar Surface Area: 80.26 Å^2
• Rotatable Bonds: 0
• Lipinski's Rule of Five: true

PROPERTIES

Physical Property

• Solubility: anhydrous ; 26.9 g/100 mL (0 °C) ; 25.5 g/100 mL (20 °C)

  ---

  heptahydrate ; 71 g/100 mL (20 °C) in water; 1.16 g/100 mL (18 °C, ether) ; slightly soluble in alcohol, glycerol ; insoluble in acetone; 710 mg/mL; H2O: soluble1 M at 20 °C, clear, colorless
• Apperance: Powder; powder (very fine); powder and chunks; slightly gray grit; white crystalline solid
• Melting Point: 1124 °C (anhydrous, decomp) ; 200 °C (monohydrate, decomp) ; 150 °C (heptahydrate, decomp) ; 2 °C (11-hydrate, decomp); 1124°C dec.; ca. 150 - 200 °C with decomposition (hydrated salt MgSO4)
• Density: 1.07 g/mL at 20 °C; 1.68; 2.66; 2.66 g/cm^3 (anhydrous) ; 2.445 g/cm^3 (monohydrate) ; 1.68 g/cm^3 (heptahydrate); 1.512 g/cm^3 (11-hydrate); ca. 1.68 g/cm^3 (hydrated salt MgSO4)
• Refractive Index: 1.523 (monohydrate) ; 1.433 (heptahydrate)
• Vapor Pressure: <0.1 mmHg ( 20 °C)
• Vapor Density: <0.01 (vs air)
• Absorption Wavelength: λ: 260 nm Amax: 0.01; λ: 260 nm Amax: 0.026; λ: 280 nm Amax: 0.01; λ: 280 nm Amax: 0.025
• Hydrophobicity(logP): -0.91
• Odor: odorless
• pH: 5.0-7.0 (25 °C); 6.5-8.5 (25 °C, 1 M in H2O)

Safety Information

• Storage Condition: Room Temperature (15-30°C), Desiccate
• Storage Warning: Hygroscopic
• RTECS: OM4500000; OM4508000
• German water hazard class: 1; nwg
• TSCA Listed: 是
• EU Index: Not listed
• Personal Protective Equipment: Eyeshields, Gloves; Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US); Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Product Information

• Purity: ≥97%; ≥97% (complexometric); ≥97% (KT); ≥98.0%; ≥98.0% (KT); ≥99.0%; ≥99.0% (calc. on dried material, KT); ≥99.5%; ≥99.99% trace metals basis; 99%; 99.0-101.0% MgSO4 basis (in dried substance); 99.5% min; 99+%
• Concentration: ~1 M in H2O; 0.1 M MgSO4; 0.5 M; 1.0 M MgSO4; 1.00 M±0.04 M
• Grade: anhydrous; for molecular biology; puriss.; puriss. p.a.; purum; purum p.a.; reagent grade; ReagentPlus®; SAJ first grade
• Packaging: pkg of 0.1 mol (24.648 g MgSO4 · 7H2O)
• Suitability: complies for appearance of solution; plant cell culture tested; suitable for cell culture; suitable for insect cell culture
• Impurities: ≤0.0015% heavy metals (as Pb); ≤0.002% total nitrogen (N); ≤0.5% CaSO4; ≤0.8% K2SO4; acidity or alkalinity, complies; DNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected; residual solvents, complies; RNases, none detected
• Cation Traces: Al: ≤1 mg/kg; Al: ≤20 mg/kg; As: ≤0.1 mg/kg; As: ≤2 mg/kg; Ba: ≤1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤1 mg/kg; Bi: ≤5 mg/kg; Ca: ≤200 mg/kg; Ca: ≤400 mg/kg; Ca: ≤5 mg/kg; Ca: ≤5000 mg/kg; Cd: ≤1 mg/kg; Cd: ≤5 mg/kg; Cd: ≤50 mg/kg; Co: ≤1 mg/kg; Co: ≤5 mg/kg; Co: ≤50 mg/kg; Cr: ≤1 mg/kg; Cr: ≤5 mg/kg; Cu: ≤1 mg/kg; Cu: ≤5 mg/kg; Cu: ≤50 mg/kg; Fe: ≤1 mg/kg; Fe: ≤10 mg/kg; Fe: ≤5 mg/kg; Fe: ≤50 mg/kg; heavy metals (as Pb): ≤5 ppm; K: ≤20 mg/kg; K: ≤200 mg/kg; K: ≤500 mg/kg; K: ≤8000 mg/kg; Li: ≤1 mg/kg; Li: ≤5 mg/kg; Mn: ≤1 mg/kg; Mn: ≤20 mg/kg; Mn: ≤5 mg/kg; Mo: ≤1 mg/kg; Mo: ≤5 mg/kg; Na: ≤100 mg/kg; Na: ≤20 mg/kg; NH4+: ≤20 mg/kg; Ni: ≤1 mg/kg; Ni: ≤5 mg/kg; Ni: ≤50 mg/kg; Pb: ≤1 mg/kg; Pb: ≤5 mg/kg; Pb: ≤50 mg/kg; Sr: ≤1 mg/kg; Sr: ≤5 mg/kg; Zn: ≤1 mg/kg; Zn: ≤5 mg/kg; Zn: ≤50 mg/kg
• Antion Traces: chloride (Cl-): ≤100 mg/kg; chloride (Cl-): ≤400 mg/kg; chloride (Cl-): ≤5 mg/kg; chloride (Cl-): ≤50 mg/kg; nitrate (NO3-): ≤40 mg/kg
• Foreign Activity: DNase, RNase, nickase and protease, none detected
• Sterility: 0.2 μm filtered
• Shelf Life: (limited shelf life, expiry date on the label)
• Loss on Drying: ≤2% loss on ignition, 600 °C; ≤26-36% loss on ignition, 500 °C; 26-32% loss on drying, 400-500 °C; 26-36% loss on ignition, 500°C
• Quality: dried; meets analytical specification of DAC; volumetric
• Factor: 1.000 ±0.002
• λ: 1 M in H2O; neat
• Product Line: BioUltra
• Linear Formula: MgSO4 · aq
• Empirical Formula (Hill Notation): MgSO4

DETAILS

MP Biomedicals - 02150136

Anhydrous
Crystalline

MP Biomedicals - 02194699

Cell Culture Reagent
Anhydrous
Crystalline

DrugBank - DB00653

• Drug Groups: approved
• Description: A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
• Indication: Used for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
• Pharmacology: Magnesium sulfate is a small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. Magnesium sulfate is gaining popularity as an initial treatment in the management of various dysrhythmias, particularly torsades de pointes, and dyrhythmias secondary to TCA overdose or digitalis toxicity.
• Toxicity: LD₅₀ = 1200 mg/kg (rat, subcutaneous). May be harmful if swallowed. May act as an irritant. Adverse reactions include hypotension, ECG changes, diarrhea, urinary retention, CNS depression and respiratory depression.
• Affected Organisms: Humans and other mammals
• Biotransformation: None
• Half Life: 43.2 hours (for newborns)
• Protein Binding: 25-30%
• Elimination: Magnesium is excreted solely by the kidney at a rate proportional to the serum concentration and glomerular filtration.
• References: [Link] ; Blitz M, Blitz S, Hughes R, Diner B, Beasley R, Knopp J, Rowe BH: Aerosolized magnesium sulfate for acute asthma: a systematic review. Chest. 2005 Jul;128(1):337-44. [Pubmed]
• External Links: Wikipedia; RxList; Drugs.com

Sigma Aldrich - M3409

Preparation Note
在 18 兆欧水中制备

Sigma Aldrich - 203726

Packaging
25, 125 g in poly bottle

Sigma Aldrich - 63126

General description
Visit our Titration Center to learn more.

Sigma Aldrich - 38146

General description
Visit our Titration Center to learn more.
concentration after dilution to 1L: 0.1mol/L; amount of substance 0.1mol (24.648 g MgSO4 · 7H2O)

Sigma Aldrich - 63135

Caution
may contain grey black particle

Sigma Aldrich - 58219

General description
Visit our Sensor Applications portal to learn more.
Other Notes
Solution used to establish a constant ionic strength in a sample solution for determinations with ISE
Preparation Note
prepared with high purity salts

Sigma Aldrich - 34276

General description
Visit our Titration Center to learn more.

Sigma Aldrich - 63137

Other Notes
Procedure for chromosome and nuclei isolation for flow cytometric analysis1

Sigma Aldrich - M7506

包装
1, 2 kg in poly bottle
12, 25 kg in poly drum
500 g in poly bottle
法律信息
ReagentPlus 注册商标 Sigma-Aldrich Co. LLC

Sigma Aldrich - 208094

Packaging
12 kg in poly drum
500 g in poly bottle
2.5 kg in poly bottle

Sigma Aldrich - 246972

Packaging
100, 500 g in poly bottle
Legal Information
ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

REFERENCES

• Blitz M, Blitz S, Hughes R, Diner B, Beasley R, Knopp J, Rowe BH: Aerosolized magnesium sulfate for acute asthma: a systematic review. Chest. 2005 Jul;128(1):337-44. Pubmed
• Link
• Suitable for the preliminary drying of organic liquids, for example solvent extracts from reaction workups.