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Tyloxapol

Catalog No. DB06439 Name DrugBank
CAS Number 25301-02-4 Website http://www.ualberta.ca/
M. F. C51H80O6 Telephone (780) 492-3111
M. W. 789.1773 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 4429

SYNONYMS

Brand Name
Alevaire
SuperVent
Synonyms
Macrocyclon

DATABASE IDS

CAS Number 25301-02-4

PROPERTIES

DETAILS

Description (English)
Item Information
Drug Groups approved; investigational
Description Tyloxapol is a non-ionic detergent often used as a surfactant.
Indication Used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions, administered by inhalation through a nebulizer or with a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications.
Pharmacology It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.
Toxicity Acute oral LD50 in 1000 mg/kg in mouse and 5000 mg/kg in rat.
Affected Organisms
Humans and other mammals
References
Bhatia AJ, Wade GN: Effects of pregnancy and ovarian steroids on fatty acid synthesis and uptake in Syrian hamsters. Am J Physiol. 1991 Jan;260(1 Pt 2):R153-8. [Pubmed]
External Links
Wikipedia
Drugs.com

REFERENCES

  • Bhatia AJ, Wade GN: Effects of pregnancy and ovarian steroids on fatty acid synthesis and uptake in Syrian hamsters. Am J Physiol. 1991 Jan;260(1 Pt 2):R153-8. Pubmed