| Item |
Information |
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Drug Groups
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approved; investigational |
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Description
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Tyloxapol is a non-ionic detergent often used as a surfactant.
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| Indication |
Used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions, administered by inhalation through a nebulizer or with a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications. |
| Pharmacology |
It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. |
| Toxicity |
Acute oral LD50 in 1000 mg/kg in mouse and 5000 mg/kg in rat. |
| Affected Organisms |
| • |
Humans and other mammals |
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| References |
| • |
Bhatia AJ, Wade GN: Effects of pregnancy and ovarian steroids on fatty acid synthesis and uptake in Syrian hamsters. Am J Physiol. 1991 Jan;260(1 Pt 2):R153-8.
[Pubmed]
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| External Links |
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