• ChemBase ID: 4429
• Molecular Formular: C51H80O6
• Molecular Mass: 789.1773
• Monoisotopic Mass: 788.59549028
• SMILES: c1(c(cc(cc1Cc1c(c(cc(c1)C(C)(C)CC(C)(C)C)C)OCCO)C(C)(C)CC(C)(C)C)Cc1c(ccc(c1)C(C)(C)CC(C)(C)C)OCCO)OCCO
• Canonical SMILES: OCCOc1c(Cc2cc(ccc2OCCO)C(CC(C)(C)C)(C)C)cc(cc1Cc1cc(cc(c1OCCO)C)C(CC(C)(C)C)(C)C)C(CC(C)(C)C)(C)C
• InChI: InChI=1S/C51H80O6/c1-35-25-41(50(13,14)33-47(5,6)7)29-37(44(35)56-23-20-53)27-39-31-42(51(15,16)34-48(8,9)10)30-38(45(39)57-24-21-54)26-36-28-40(17-18-43(36)55-22-19-52)49(11,12)32-46(2,3)4/h17-18,25,28-31,52-54H,19-24,26-27,32-34H2,1-16H3
• InChIKey: UTFVNNPSMPINLE-UHFFFAOYSA-N

NAMES AND DATABASE IDS

Names

• Brand Name: SuperVent; Alevaire
• Synonyms: Macrocyclon; Tyloxapol

Database IDs

• CAS Number: 25301-02-4
• PubChem SID: 160967861
• PubChem CID: 70789242

DETAILS

DrugBank - DB06439

• Drug Groups: approved; investigational
• Description: Tyloxapol is a non-ionic detergent often used as a surfactant.
• Indication: Used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions, administered by inhalation through a nebulizer or with a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications.
• Pharmacology: It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins.
• Toxicity: Acute oral LD50 in 1000 mg/kg in mouse and 5000 mg/kg in rat.
• Affected Organisms: Humans and other mammals
• References: Bhatia AJ, Wade GN: Effects of pregnancy and ovarian steroids on fatty acid synthesis and uptake in Syrian hamsters. Am J Physiol. 1991 Jan;260(1 Pt 2):R153-8. [Pubmed]
• External Links: Wikipedia; Drugs.com

REFERENCES

• Bhatia AJ, Wade GN: Effects of pregnancy and ovarian steroids on fatty acid synthesis and uptake in Syrian hamsters. Am J Physiol. 1991 Jan;260(1 Pt 2):R153-8. Pubmed