Sitagliptin

• Catalog No.: Bio-0943
• CAS Number: 486460-32-6
• M. F.: C16H15F6N5O
• M. W.: 407.3136192

SYNONYMS

• IUPAC name: (3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• IUPAC Traditional name: (3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
• Synonyms: MK-0431

DATABASE IDS

• CAS Number: 486460-32-6

PROPERTIES

• Application(s): Antidiabetic drug
• Mechanism of Action: Dipeptidyl peptidase-4 (DPP-4) inhibitor

REFERENCES

• Herman GA; Stevens C, Van Dyck K, Bergman A, Yi B, De Smet M, Snyder K, Hilliard D, Tanen M, Tanaka W, Wang AQ, Zeng W, Musson D, Winchell G, Davies MJ, Ramael S, Gottesdiener KM, Wagner JA.
• "Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind,
• placebo-controlled studies with single oral doses". Clin Pharmacol Ther 78 (6): 675?8. (December 2005)