Darifenacin hydrobromide

• Catalog No.: Bio-0941
• CAS Number: 133099-07-7
• M. F.: C28H31BrN2O2
• M. W.: 507.46194

SYNONYMS

• IUPAC name: 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide hydrobromide
• IUPAC Traditional name: 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide hydrobromide
• Synonyms: Emselex; Enablex

DATABASE IDS

• CAS Number: 133099-07-7

PROPERTIES

• Application(s): Used to treat urinary incontinence
• Salt Data: HBr
• Mechanism of Action: Works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions

REFERENCES

• Liver Physiol. 2010 Jul;299(1):G215-9. Epub 2010 Apr 15.
• 3. Jha S, Parsons M: Treatment of overactive bladder in the aging population: focus on darifenacin. Clin Interv Aging. 2006;1(4):309-16.
• 1. Bharucha AE, Ravi K, Zinsmeister AR: Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans. Am J Physiol Gastrointest
• 2. Bozkurt TE, Sahin-Erdemli I: M(1) and M(3) muscarinic receptors are involved in the release of urinary bladder-derived relaxant factor. Pharmacol Res. 2009 May;59(5):300-5. Epub 2009 Feb 5.