Tolvaptan

• Catalog No.: Bio-0936
• CAS Number: 150683-30-0
• M. F.: C26H25ClN2O3
• M. W.: 448.9413

SYNONYMS

• IUPAC name: N-{4-[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl]-3-methylphenyl}-2-methylbenzamide
• IUPAC Traditional name: N-{4-[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl]-3-methylphenyl}-2-methylbenzamide
• Synonyms: Samsca; OPC-41061

DATABASE IDS

• CAS Number: 150683-30-0

PROPERTIES

• Mechanism of Action: Vasopressin V2 receptor antagonist
• Application(s): Used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).

REFERENCES

• 2. Shoaf S, Elizari M, Wang Z et al. (2005). "Tolvaptan administration does not affect steady state amiodarone concentrations in patients with cardiac arrhythmias". J Cardiovasc Pharmacol Ther 10 (3):
• 165?1.
• 3. Gheorghiade M, Gattis W, O'Connor C et al. (2004). "Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial". JAMA 291 (
• 16): 1963?1.
• 1. Gheorghiade M, Niazi I, Ouyang J et al. (2003). "Vasopressin V2-receptor blockade with tolvaptan in patients with chronic heart failure: results from a double-blind, randomized trial". Circulation
• 107 (21): 2690?