Zileuton

• Catalog No.: Bio-0924
• CAS Number: 111406-87-2
• M. F.: C11H12N2O2S
• M. W.: 236.29018

SYNONYMS

• IUPAC name: 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
• IUPAC Traditional name: 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
• Synonyms: Leutrol; ZYFLO; Zyflo CR

DATABASE IDS

• CAS Number: 111406-87-2

PROPERTIES

• Application(s): Antiallergic
• Application(s): Antiinflammatory agent
• Application(s): Potential antiasthmatic agent
• Application(s): Investigated for treatment of irritable bowel disease
• Mechanism of Action: 5-Lipoxygenase (5-LOX) inhibitor
• Mechanism of Action: inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation
• Mechanism of Action: weak inhibitor of CYP 1A2

REFERENCES

• 1. Malo PE, Bell RL, Shaughnessy TK, Summers JB, Brooks DW, Carter GW. The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis.
• Pulm Pharmacol. 1994 Apr;7(2):73-9
• 2. Lu P, Schrag ML, Slaughter DE, Raab CE, Shou M, Rodrigues AD. Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
• Drug Metab Dispos. 2003 Nov;31(11):1352-60.