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Sirolimus

Catalog No. Bio-0918 Name InterBioScreen
CAS Number 53123-88-9 Website http://www.ibscreen.com
M. F. C51H79NO13 Telephone +7 49652 40091
M. W. 914.17186 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 179897

SYNONYMS

IUPAC name
(1R,9S,12R,15R,16E,18S,19S,21R,23R,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1R,3S,4S)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
IUPAC Traditional name
(1R,9S,12R,15R,16E,18S,19S,21R,23R,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1R,3S,4S)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
Synonyms
Rapamycin

DATABASE IDS

CAS Number 53123-88-9

PROPERTIES

Application(s) Polyene-type antibiotic
Application(s) Antifungal agent
Application(s) Possesses antineoplastic and immunosuppressant props.
Biological Source Prod. by Streptomyces hygroscopicus
Description Rotamers (8:2)
Mechanism of Action Inhibits the response to interleukin-2 (IL-2) and thereby blocks activation of T- and B-cells

DETAILS

REFERENCES

  • Baker, H. et al., J. Antibiot., 1978, 31, 539; 1979, 32, 630
  • Morris, R.E. et al., Transpl. Rev., 1992, 16, 39-87