Geniposide

• Catalog No.: Bio-0907
• CAS Number: 24512-63-8
• M. F.: C17H24O10
• M. W.: 388.36646

SYNONYMS

• IUPAC name: methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,7aH-cyclopenta[c]pyran-4-carboxylate
• IUPAC Traditional name: methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,7aH-cyclopenta[c]pyran-4-carboxylate
• Synonyms: Jasminoidin; Genipin 1-glucoside

DATABASE IDS

• CAS Number: 24512-63-8

PROPERTIES

• Application(s): Antitumor
• Application(s): Anti-angiogenic
• Application(s): Anti-inflammatory
• Application(s): Antithrombotic
• Application(s): Neuroprotective
• Biological Source: Constit. of Gardenia jasminoides
• Mechanism of Action: Glucagon-like peptide-1 (GLP-1) receptor agonist

REFERENCES

• 1. Hsua HY, Yangb JJ, Lina SY, Lin CC. Comparisons of geniposidic acid and previous termgeniposidenext term on antitumor and radioprotection after sublethal irradiation,
• Cancer Lett. 113 (1997), pp. 31?7.
• 2. Koo HJ, Lee S, Shin KH, Kim BC, Lim CJ, Park EH. Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides. Planta Med. 2004 May;70(5):467-9.
• 3. Koo HJ, Lim KH, Jung HJ, Park EH. Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. J Ethnopharmacol. 2006 Feb 20;103(3):496-500. Epub 2005 Sep 19.
• 4. Suzuki Y, Kondo K, Ikeda Y, Umemura K. Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Med. 2001 Dec;67(9):807-10.
• 5. Lee P, Lee J, Choi SY, Lee SE, Lee S, Son D. Geniposide from Gardenia jasminoides attenuates neuronal cell death in oxygen and glucose deprivation-exposed rat hippocampal slice culture.
• Biol Pharm Bull. 2006 Jan;29(1):174-6.
• 6. Liu J, Yin F, Zheng X, Jing J, Hu Y. Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway.
• Neurochem Int. 2007 Nov-Dec;51(6-7):361-9. Epub 2007 May 6.