Glabridin

• Catalog No.: Bio-0904
• CAS Number: 59870-68-7
• M. F.: C20H20O4
• M. W.: 324.3704

SYNONYMS

• IUPAC name: 4-[(5R)-12,12-dimethyl-3,11-dioxatricyclo[8.4.0.0^2,^7]tetradeca-1,7,9,13-tetraen-5-yl]benzene-1,3-diol
• IUPAC Traditional name: 4-[(5R)-12,12-dimethyl-3,11-dioxatricyclo[8.4.0.0^2,^7]tetradeca-1,7,9,13-tetraen-5-yl]benzene-1,3-diol
• Synonyms: 4-[3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-1,3-benzenediol

DATABASE IDS

• CAS Number: 59870-68-7

PROPERTIES

• Application(s): Cytotoxic
• Application(s): Antimicrobial
• Application(s): Estrogenic
• Application(s): Anti-proliferative
• Application(s): Anti-inflammatory
• Biological Source: Isol. from Glycyrrhiza glabra
• Mechanism of Action: Tyrosinase inhibitor
• Mechanism of Action: Human cytochrome P450S 3A4, 2B6, 2C9 inhibitor
• Mechanism of Action: Melanogenesis inhibitor

REFERENCES

• 1. T. Fukai, H. Sakagami, M. Toguchi, F. Takayama, I. Iwakura and T. Atsumi, Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines,
• Anticancer Res 20 (2000), pp. 2525?536.
• 2. T. Fukai, A. Marumo, K. Kaitou, T. Kanda, S. Terada and T. Nomura, Anti-Helicobacter pylori flavonoids from licorice extract, Life Sci 71 (2002), pp. 1449?463
• 3. S. Tamir, M. Eizenberg, D. Somjen, S. Izrael and J. Vaya, Estrogen-like activity of glabrene and other constituents isolated from licorice root, J Steroid Biochem Mol Biol 78 (2001), pp. 291?98.
• 4. T. Yokota, H. Nishio, Y. Kubota and M. Mizoguchi, The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation, Pigment Cell Res 11 (1998), pp. 355?61.
• 5. O. Nerya, J. Vaya, R. Musa, S. Izrael, R. Ben-Arie and S. Tamir, Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots, J Agric Food Chem 51 (2003), pp. 1201?207.
• 6. U.M. Kent, M. Aviram, M. Rosenblat and P.F. Hollenberg, The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9,
• Drug Metab Dispos 30 (2002), pp. 709?15.
• 7. Choi, E. The licorice root derived isoflavan glabridin increases the function of osteoblastic
• MC3T3-E1 cells. Biochem. Pharm. 2005, 70, 363-368.