d-Bicuculline

• Catalog No.: Bio-0900
• CAS Number: 485-49-4
• M. F.: C20H17NO6
• M. W.: 367.35208

SYNONYMS

• IUPAC name: (10R)-10-[(5S)-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3,5,11-trioxatricyclo[7.3.0.0^2,^6]dodeca-1(9),2(6),7-trien-12-one
• IUPAC Traditional name: (10R)-10-[(5S)-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3,5,11-trioxatricyclo[7.3.0.0^2,^6]dodeca-1(9),2(6),7-trien-12-one

DATABASE IDS

• CAS Number: 485-49-4

PROPERTIES

• Application(s): Mimics epilepsy.
• Application(s): Utilised in the in vitro study of epilepsy.
• Biological Source: Alkaloid from many Corydalis spp. and several Fumaria spp. (opt. rotn. of isolates not recorded in some cases). Also isol. from Adlumia fungosa (Adlumia cirrhosa) (Fumariaceae, Papaveraceae)
• Mechanism of Action: GABA(A)-receptor antagonist

REFERENCES

• 1. Manske, Can. J. Res. 7:265, 1932
• 2. Khawaled R, Bruening-Wright A, Adelman JP, Maylie J (1999) Bicuculline block of small-conductance calcium-activated potassium channels. Pflugers Arch 438: 314-321