Barbaloin

• Catalog No.: Bio-0895
• CAS Number: 1415-73-2
• M. F.: C21H22O9
• M. W.: 418.39398

SYNONYMS

• IUPAC name: (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one
• IUPAC Traditional name: (10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one
• Synonyms: Aloin A

DATABASE IDS

• CAS Number: 1415-73-2

PROPERTIES

• Application(s): Purgative
• Application(s): Laxative
• Biological Source: Constit. of various Aloe spp.
• Mechanism of Action: Na+, K(+)-adenosine triphosphatase (ATPase) inhibitor
• Mechanism of Action: Increase prostaglandin synthesis

REFERENCES

• 1. Akao T, Che QM, Kobashi K, Hattori M, Namba T.
• A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe, capable of transforming barbaloin to aloe-emodin anthrone. Biol Pharm Bull. 1996 Jan;19(1):136-8.
• 2. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. III. Mechanism of cathartic effect. (2). Chem Pharm Bull (Tokyo). 1990 Jan;38(1):197-200.
• 3. Capasso F, Mascolo N, Autore G, Duraccio MR. Effect of indomethacin on aloin and 1,8 dioxianthraquinone-induced production of prostaglandins in rat isolated colon.
• Prostaglandins. 1983 Oct;26(4):557-62.