Aloe emodin

• Catalog No.: Bio-0894
• CAS Number: 481-72-1
• M. F.: C15H10O5
• M. W.: 270.2369

SYNONYMS

• IUPAC name: 1,8-dihydroxy-3-(hydroxymethyl)-9,10-dihydroanthracene-9,10-dione
• IUPAC Traditional name: 1,8-dihydroxy-3-(hydroxymethyl)-9,10-dihydroanthracene-9,10-dione
• Synonyms: Aloe-emodin; Rhabarberone; Aloeemodin

DATABASE IDS

• CAS Number: 481-72-1

PROPERTIES

• Application(s): Antitumor
• Application(s): Antileukaemic
• Application(s): Cathartic
• Application(s): Antiseptic
• Application(s): Antimicrobial
• Application(s): Antimutagenic
• Application(s): Antibacterial
• Biological Source: Present in aloe latex, an exudate from the aloe plant
• Mechanism of Action: Apoptosis inducer
• Mechanism of Action: Protein kinase C (PKC) inhibitor
• Mechanism of Action: Caspase-3 activator
• Mechanism of Action: Caspase-8 activator
• Mechanism of Action: Caspase-9 activator

REFERENCES

• 1. Hatano T, Uebayashi H, Ito H, Shiota S, Tsuchiya T, Yoshida T.
• Phenolic constituents of Cassia seeds and antibacterial effect of some naphthalenes and anthraquinones on methicillin-resistant Staphylococcus aureus. Chem Pharm Bull (Tokyo). 1999 Aug;47(8):1121-7.
• 2. Hofilena, J., Ragasa, C.Y., Rideout, J.A. An antimicrobial and antimutagenic anthraquinone from Cassia alata. ACGC Chemical Research Communications, 2000, 10:15-20.
• 3. Chen SH, Lin KY, Chang CC, Fang CL, Lin CP. Aloe-emodin-induced apoptosis in human gastric carcinoma cells. Food Chem Toxicol. 2007 Nov;45(11):2296-303. Epub 2007 Jun 12.
• 4. Acevedo-Duncan M, Russell C, Patel S, Patel R. Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells.
• Int Immunopharmacol. 2004 Dec 20;4(14):1775-84.