Zidovudine

• Catalog No.: Bio-0890
• CAS Number: 30516-87-1
• M. F.: C10H13N5O4
• M. W.: 267.24132

SYNONYMS

• IUPAC name: 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
• IUPAC Traditional name: 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
• Synonyms: 3'-Azido-3'-deoxythymidine; Retrovir; Apovir; 3'-Azidothymidine; Novo-AZT; Zidovir

DATABASE IDS

• CAS Number: 30516-87-1

PROPERTIES

• Application(s): Antiviral agent active exclusively against retroviruses, esp. AIDS virus and leukaemias
• Application(s): Drugs of choice for AIDS treatment
• Mechanism of Action: Reverse Transcriptase Inhibitor
• Mechanism of Action: Nucleoside transporter substrate

REFERENCES

• 1. Mitsuya H, Yarchoan R, Broder S: Molecular targets for AIDS therapy. Science. 1990 Sep 28;249(4976):1533-44.
• 2. Mitsuya H, Weinhold KJ, Furman PA, St Clair MH, Lehrman SN, Gallo RC, Bolognesi D, Barry DW, Broder S: 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and
• cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc Natl Acad Sci U S A. 1985 Oct;82(20):7096-100.
• 3. Yarchoan R, Mitsuya H, Broder S: AIDS therapies. Sci Am. 1988 Oct;259(4):110-9.
• 4. De Clercq E: HIV resistance to reverse transcriptase inhibitors. Biochem Pharmacol. 1994 Jan 20;47(2):155-69.
• 5. Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O'Sullivan MJ, VanDyke R, Bey M, Shearer W, Jacobson RL, et al.: Reduction of maternal-infant transmission
• of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med. 1994 Nov 3;331(18):1173-80.