Doxazosin mesylate

• Catalog No.: Bio-0889
• CAS Number: 74191-85-8
• M. F.: C24H29N5O8S
• M. W.: 547.58076

SYNONYMS

• IUPAC name: 2-[4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine; methanesulfonic acid
• IUPAC Traditional name: 2-[4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine; methanesulfonic acid
• Synonyms: Cardura; Diblocin; Alfadil; Cardular; Cardenalin; Normothen; Supressin; Carduran

DATABASE IDS

• CAS Number: 74191-85-8

PROPERTIES

• Application(s): Antihypertensive agent
• Application(s): Used in the treatment of benign prostatic hyperplasia
• Salt Data: Mesylate
• Mechanism of Action: alpha-1-Adrenoceptor antagonist
• Mechanism of Action: Alters serum lipid profile via increase in LDL-receptor activity and other effects

REFERENCES

• Ger. Pat., 1979, Wellcome Foundation, 2 847 623; CA, 91, 74649u, (synth)
• Ali, F.K. et al., Br. J. Pharmacol., 1980, 68, 113P, (pharmacol)
• Rubin, P.C. et al., J. Chromatogr., 1980, 221, 193, (hplc)
• Elliott, H.L. et al., Br. J. Clin. Pharmacol., 1982, 13, 699, (pharmacol)
• Elliott, H.L. et al., Am. J. Cardiol., 1987, 59, 78G, (pharmacokinet, rev)
• Campbell, S.F. et al., J. Med. Chem., 1987, 30, 49; 1988, 31, 1031; 1036, (synth, pharmacol, sar)
• Young, R.A. et al., Drugs, 1988, 35, 525, (rev)
• Pool, J.L., Am. Heart J., 1991, 121, 251, (pharmacol, rev)
• Babamoto, K.S. et al., Clin. Pharm., 1992, 11, 415, (rev)
• Langdon, C.G. et al., Br. J. Clin. Pract., 1994, 48, 293, (clin trial)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 9440, (synonyms)
• Pat. Coop. Treaty (WIPO), 1994, Sepracor, 94 9 782; CA, 121, 42780b, (pharmacol, enantiomers)
• Pat. Coop. Treaty (WIPO), 1994, Sepracor, 94 9 786; CA, 121, 42782d, (pharmacol, enantiomers)
• Pat. Coop. Treaty (WIPO), 1994, Sepracor, 94 9 783; CA, 121, 42781c, (pharmacol, enantiomers)
• Fulton, B. et al., Drugs, 1995, 49, 295, (rev)
• Hatano, A. et al., Eur. J. Pharmacol., 1996, 313, 135-143, (pharmacol, enantiomers)
• McCullough, J.R. et al., Pharmacol. Rev. Commun., 1997, 9, 191-196; CA, 1997, 127, 243207t, (pharmacol, enantiomers)