Home > Compound List > Product Information
Amiloride hydrochloride_Molecular_structure_CAS_2016-88-8)
Click picture or here to close

Amiloride hydrochloride

Catalog No. Bio-0885 Name InterBioScreen
CAS Number 2016-88-8 Website http://www.ibscreen.com
M. F. C6H9Cl2N7O Telephone +7 49652 40091
M. W. 266.08796 Fax
Purity Email screen@ibscreen.chg.ru
Storage Chembase ID: 72807


IUPAC name
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride
IUPAC Traditional name
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride


CAS Number 2016-88-8


Application(s) Potassium-sparing diuretic
Salt Data HCl
Mechanism of Action Inhibitor of sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels.
Mechanism of Action This promotes the loss of sodium and water from the body, but without depleting potassium.
Mechanism of Action Amiloride exerts its potassium sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule and collecting duct;
Mechanism of Action this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion.
Mechanism of Action Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone.



  • Cragoe, E.J. et al., J. Med. Chem., 1967, 10, 66, (synth, pharmacol)
  • Smith, R.L. et al., J.A.C.S., 1979, 101, 191, (pmr, cmr, N-15 nmr, tautom)
  • Burns, D.T. et al., Anal. Chim. Acta, 1980, 118, 185, (detn, ClO(-))
  • Hyams, D.E., Int. Congr. Symp. Ser. R. Soc. Med., 1981, 44, 65, (rev)
  • Laragh, J.H., Curr. Ther. Res., 1982, 32, 173, (rev)
  • Martindale, The Extra Pharmacopoeia, 28th/29th edn., Pharmaceutical Press, 1982, 2304
  • Mazzo, D.J., Anal. Profiles Drug Subst., 1986, 15, 1, (rev)
  • Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 445, (synonyms)
  • Amiloride and its Analogs, (eds. Cragoe, E.J. et al), VCH, New York, 1992, (book)
  • Buono, R.A. et al., J.A.C.S., 1994, 116, 1502, (conformn)