lovastatin

• Catalog No.: Bio-0873
• CAS Number: 75330-75-5
• M. F.: C24H36O5
• M. W.: 404.53964

SYNONYMS

• IUPAC name: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• IUPAC Traditional name: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
• Synonyms: Mevinacor; Nergadan; Mevacor; Monacolin K; Tancor; Lipofren

DATABASE IDS

• CAS Number: 75330-75-5

PROPERTIES

• Biological Source: Metab. of Aspergillus terreus and Monascus ruber
• Application(s): Antihyperlipidaemic agent
• Mechanism of Action: Inhibitor of cholesterol biosynthesis
• Mechanism of Action: Potent inhibitor of HMG-CoA

REFERENCES

• Alberts et al (1980) Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc.Natl.Acad.Sci.USA 77 3957.