Cyclosporin A

• Catalog No.: Bio-0872
• CAS Number: 59865-13-3
• M. F.: C62H111N11O12
• M. W.: 1202.61124

SYNONYMS

• IUPAC name: (12R)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
• IUPAC Traditional name: (12R)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
• Synonyms: Sandimmun; Cyclosporine; Sandimmune; Neoral; Cyclorin; Ramihyphin A

DATABASE IDS

• CAS Number: 59865-13-3

PROPERTIES

• Application(s): Possesses antifungal activity and immunosuppressive props. with a specific action on T-lymphocytes
• Application(s): Used clinically as an immunosuppressant after transplant surgery
• Biological Source: Metab. of Trichoderma inflatum (previously Trichoderma polysporum). Also isol. from Fusarium solani and Tolypocladium sinense
• Description: Conformers
• Mechanism of Action: Calcineurin inhibitor

REFERENCES

• Merck Index 12 2821. Fruman et al (1992) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc.Natl.Acad.Sci.USA 89 3686.