m-Chlorophenylbiguanide

• Catalog No.: Bio-0861
• CAS Number: 48144-44-1
• M. F.: C8H10ClN5
• M. W.: 211.6515

SYNONYMS

• IUPAC name: 1-carbamimidamido-N-(3-chlorophenyl)methanimidamide
• IUPAC Traditional name: 1-carbamimidamido-N-(3-chlorophenyl)methanimidamide
• Synonyms: 1-(3-Chlorophenyl)biguanide

DATABASE IDS

• CAS Number: 48144-44-1

PROPERTIES

• Application(s): Psychostimulant
• Application(s): Tranquilizer
• Mechanism of Action: Potent selective serotonin 5-HT3 receptor agonist

REFERENCES

• 1. Parihar HS,Kirschbaum KS (2002)
• Electrostatic potential surfaces of 5-HT(3)R agonists suggest accessory cation-pi site adjacent to agonist binding domain.
• Bioorganic & medicinal chemistry letters 12, 2743-7
• 2. Dukat M,Abdel-Rahman AA,Ismaiel AM,Ingher S,Teitler M,Gyermek L,Glennon RA (1996)
• Structure-activity relationships for the binding of arylpiperazines and arylbiguanides at 5-HT3 serotonin receptors.
• Journal of medicinal chemistry 39, 4017-26
• 3. Zhou Y,Peng H,Ji Q,Qi J,Zhu Z,Yang C (2006)
• Discovery of small molecule inhibitors of integrin alphavbeta3 through structure-based virtual screening.
• Bioorganic & medicinal chemistry letters 16, 5878-82
• 4. Rahman AA,Daoud MK,Dukat M,Herrick-Davis K,Purohit A,Teitler M,do Amaral AT,Malvezzi A,Glennon RA (2003) Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin
• receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG). Bioorganic & medicinal chemistry letters 13, 1119-23
• 5. Dukat M,Choi YN,Teitler M,Du Pre A,Herrick-Davis K,Smith C,Glennon RA (2001)
• The binding of arylguanidines at 5-HT(3) serotonin receptors: a structure-affinity investigation.
• Bioorganic & medicinal chemistry letters 11, 1599-603