Psoralen

• Catalog No.: Bio-0831
• CAS Number: 66-97-7
• M. F.: C11H6O3
• M. W.: 186.16354

SYNONYMS

• IUPAC name: 7H-furo[3,2-g]chromen-7-one
• IUPAC Traditional name: 7H-furo[3,2-g]chromen-7-one
• Synonyms: Ficusin; Furo[4',5':6,7]coumarin

DATABASE IDS

• CAS Number: 66-97-7

PROPERTIES

• Application(s): An important use of psoralen is in PUVA treatment for skin problems such as psoriasis and (to a lesser extent) eczema and vitiligo.
• Application(s): This takes advantage of the high UV absorbance of psoralen
• Biological Source: From Psoralea corylifolia, Ficus salicifolia, Heracleum leskovii, Ruta chalepensis, Dictamnus hispanicus, etc. Found in common vegetables, e.g. parsnip, celery esp. if diseased or `spoiled'
• Mechanism of Action: Radiosensitizer

REFERENCES

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 173A, (nmr)
• Worden, L.R. et al., J.O.C., 1969, 34, 2311, (synth)
• Pardanani, N.H. et al., Aust. J. Chem., 1972, 25, 1537, (synth)
• Austin, D.H. et al., Phytochemistry, 1973, 12, 1657, (biosynth)
• Chatterjee, A. et al., Indian J. Chem., Sect. B, 1977, 15, 212, (synth, uv, pmr)
• Bergenthal, D. et al., Arch. Pharm. (Weinheim, Ger.), 1978, 311, 1026, (cmr)
• Matsumoto, H. et al., Chem. Pharm. Bull., 1978, 26, 3433, (uv)
• Reisch, J. et al., Chem. Ber., 1979, 112, 1491, (synth)
• Murray, R.D.H. et al., The Natural Coumarins, J. Wiley, 1982, (rev)
• Beier, R.C. et al., Xenobiotics in Foods and Feeds, Amer. Chem. Soc., 1983, 295, (occur)
• Hayakawa, K. et al., J.A.C.S., 1984, 106, 6735, (synth)
• Ceska, O. et al., Experientia, 1986, 42, 1302, (occur, tox)
• Zubia, E. et al., Tetrahedron, 1992, 48, 4239, (synth)
• Masuda, T. et al., Phytochemistry, 1998, 47, 13-16, (isol, uv, pmr, cmr)
• Chimichi, S. et al., Tetrahedron, 2002, 58, 4859-4863, (synth)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, FQD000