Bergapten

• Catalog No.: Bio-0829
• CAS Number: 484-20-8
• M. F.: C12H8O4
• M. W.: 216.18952

SYNONYMS

• IUPAC name: 4-methoxy-7H-furo[3,2-g]chromen-7-one
• IUPAC Traditional name: 4-methoxy-7H-furo[3,2-g]chromen-7-one
• Synonyms: Majudin; Heraclin

DATABASE IDS

• CAS Number: 484-20-8

PROPERTIES

• Application(s): Antipsoriatic
• Application(s): Antiinflammatory
• Application(s): Antihistamine agent
• Application(s): Show spasmolytic props
• Application(s): Used in the treatment of vitiligo
• Biological Source: Major constit. of bergamot oil (Citrus bergamia), also from Heracleum giganteum and Ammi majus. Widely distributed in the Rutaceae and Umbelliferae
• Mechanism of Action: Spasmolytic
• Mechanism of Action: Radiosensitizer

REFERENCES

• Kawaii, S. et al., J. Agric. Food Chem., 1999, 47, 4073, (activity)
• Oliva, A. et al., J. Chem. Ecol., 1999, 25, 519-526, (activity)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MFN275
• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 1321A, (nmr)
• Baetcke, E. et al., Ber., 1912, 45, 3705, (struct)
• Glatfelder, A. et al., Helv. Chim. Acta, 1920, 3, 541; 1921, 4, 718, (synth)
• Socias, L. et al., Ber., 1934, 67, 59, (isol)
• Kubiczek, G. et al., Ber., 1937, 70, 1253, (synth)
• Karrer, W. et al., Konstitution und Vorkommen der Organischen Pflanzenstoffe, 2nd edn., Birkhuser Verlag, Basel, 1972, no. 1369, (occur, deriv)
• Austin, D.J. et al., Phytochemistry, 1973, 12, 1657, (biosynth)
• Boyd, R.K. et al., Can. J. Chem., 1979, 57, 1995, (ms)
• Duddeck, H. et al., Phytochemistry, 1979, 18, 139, (cmr)
• IARC Monog., 1986, 40, 327, (tox, rev)
• Gu, Z. et al., Chem. Pharm. Bull., 1990, 38, 2498, (deriv)
• Ginderow, D., Acta Cryst. C, 1991, 47, 2144, (cryst struct)
• Diawara, M.M. et al., J. Agric. Food Chem., 1995, 43, 723-727, (occur)
• Masuda, T. et al., Phytochemistry, 1998, 47, 13-16, (Bergapten, isol, pmr, cmr)