Sulfadiazine

• Catalog No.: Bio-0818
• CAS Number: 68-35-9
• M. F.: C10H10N4O2S
• M. W.: 250.277

SYNONYMS

• IUPAC name: 4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide
• IUPAC Traditional name: 4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide
• Synonyms: Triple Sulfas; Sulfadiazine; Sulfose; Triple Sulfa; Triple Sulfoid; Lantrisul; Neotrizine; Sulfaloid; Sulfonamides Duplex; Terfonyl

DATABASE IDS

• CAS Number: 68-35-9

PROPERTIES

• Application(s): Antibacterial agent
• Application(s): Used in some countries for control of bacterial disease in farmed fish
• Mechanism of Action: Folate antagonist
• Mechanism of Action: Restrict folate synthesis through competitive antagonism of PABA
• Mechanism of Action: Folate synthesis inhibitor

REFERENCES

• Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 392A, (nmr)
• Roblin, R.O., J.A.C.S., 1940, 62, 2002, (synth)
• Bass, A.D., Drill's Pharmacol. Med., 4th edn., McGraw-Hill, New York, 1971, 1657, (rev, pharmacol)
• Chang, C.J. et al., J. Med. Chem., 1975, 18, 505, (pmr)
• Kracmar, J. et al., Pharmazie, 1975, 30; 447, (uv)
• Przybylski, M. et al., Adv. Mass Spectrom. Biochem. Med., Proc. Int. Symp. Mass Spectrom. Biochem. Med. 2nd, 3rd, 1976, 1, 309, (ms)
• Stober, H. et al., Anal. Profiles Drug Subst., 1982, 11, 523; 1984, 13, 553, (rev, synth, pharmacol, anal)
• Cai, E., CA, 1982, 96, 57702, (synth)
• Sigel, C.W., Handb. Exp. Pharmacol., 1983, 64, 163, (rev, metab)
• Joshi, V.V. et al., Indian J. Phys., A, 1983, 57, 79, (cryst struct)
• Bult, A., Pharm. Weekbl., Sci. Ed., 1983, 5, 77, (cmr, tautom)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 1477
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 201; 206
• Kokila, M.K. et al., Acta Cryst. C, 1995, 51, 333, (cryst struct)
• Gehring, T.A. et al., J. Agric. Food Chem., 1996, 44, 3164-3169, (anal)
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MRM250; SNI425; PPP500