Aprofene

• Catalog No.: Bio-0805
• CAS Number: 3563-01-7
• M. F.: C21H27NO2
• M. W.: 325.44458

SYNONYMS

• IUPAC name: 2-(diethylamino)ethyl 2,2-diphenylpropanoate
• IUPAC Traditional name: 2-(diethylamino)ethyl 2,2-diphenylpropanoate

DATABASE IDS

• CAS Number: 3563-01-7

PROPERTIES

• Application(s): Spasmolytic, anticholinergic agent
• Application(s): Used in combination therapies as a prophylactic against organophosphate poisoning
• Mechanism of Action: Spasmolytic
• Mechanism of Action: Nicotinic and selective muscarinic M 1 -receptor antagonist
• Mechanism of Action: Parasympatholytic

REFERENCES

• Zaugg, H.E. et al., J.A.C.S., 1950, 72, 3004, (synth)
• U.K. Pat., 1950, A Wander, 641 573; CA, 45, 2507a, (synth)
• Mashkovskii, M.D. et al., Farmakol. Toksikol. (Moscow), 1957, 20, 42, (pharmacol)
• Volkova, Z.V., Farmakol. Toksikol. (Moscow), 1959, 22, 345, (pharmacol)
• Ioffe, D.V. et al., Khim.-Farm. Zh., 1969, 3, 30, (synth)
• Agadzhanyan, T.E. et al., Arm. Khim. Zh., 1973, 26, 964, (ms)
• Eck, W.S. et al., J. Chromatogr., 1981, 219, 171, (hplc)
• Thompson, E.B. et al., Arch. Int. Pharmacodyn. Ther., 1984, 269, 42, (synth, pharmacol)
• Leadbeater, L. et al., Fundam. Appl. Toxicol., 1985, 5, S225, (use)
• Lu, M.C., J. Med. Chem., 1987, 30, 273, (synth)
• Leader, H. et al., J. Med. Chem., 1989, 32, 1522, (sar)
• Karle, J.M. et al., Acta Cryst. B, 1990, 46, 215, (cryst struct)
• Brown, N.D. et al., J. Chromatogr., 1991, 563, 466, (metab)
• Brown, N.D. et al., J. Pharm. Sci., 1993, 82, 563, (metab)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 418