Isoxicam

• Catalog No.: Bio-0802
• CAS Number: 34552-84-6
• M. F.: C14H13N3O5S
• M. W.: 335.33512

SYNONYMS

• IUPAC name: 4-hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,1-dioxo-2H-1λ^6,2-benzothiazine-3-carboxamide
• IUPAC Traditional name: 4-hydroxy-2-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,1-dioxo-2H-1λ^6,2-benzothiazine-3-carboxamide

DATABASE IDS

• CAS Number: 34552-84-6

PROPERTIES

• Application(s): Antiinflammatory
• Application(s): Antipyretic agent
• Application(s): Analgesic
• Mechanism of Action: Prostaglandin antagonist

REFERENCES

• DiPasquale, G. et al., Agents Actions, 1975, 5, 256, (pharmacol)
• Zinnes, H. et al., J. Med. Chem., 1982, 25, 12, (synth, pharmacol)
• Yakatan, G.J., Semin. Arthritis Rheum., 1982, 12, 153, (rev)
• DiPasquale, G., Drugs of Today (Barcelona), 1983, 19, 119, (rev)
• Borondy, P.E. et al., Drug Metab. Dispos., 1984, 12, 444, (metab)
• Svoboda, J. et al., Coll. Czech. Chem. Comm., 1986, 51, 1133, (synth)
• Dalla Croce, P. et al., J. Chem. Res., Synop., 1986, 150, (synth)
• Woolf, T.F. et al., Drug Metab. Dispos., 1989, 17, 662, (metab, exp)
• Woolf, T.F. et al., Eur. J. Drug Metab. Pharmacokinet., 1992, 17, 21, (metab, human)
• Tsai, R. et al., Helv. Chim. Acta, 1993, 76, 842, (pKa, props)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 21