Sulfamethoxazole

• Catalog No.: Bio-0801
• CAS Number: 723-46-6
• M. F.: C10H11N3O3S
• M. W.: 253.27764

SYNONYMS

• IUPAC name: 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide
• IUPAC Traditional name: 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide
• Synonyms: Gantanol

DATABASE IDS

• CAS Number: 723-46-6

PROPERTIES

• Application(s): Sulfonamide bacteriostatic antibiotic
• Application(s): Used in treatment of respiratory and urinary tract infections
• Mechanism of Action: Folate antagonist
• Mechanism of Action: Folate synthesis inhibitor
• Mechanism of Action: Restrict folate synthesis through competitive antagonism of PABA

REFERENCES

• U.K. Pat., 1959, 814276; CA, 55, 20091c, (synth)
• Fujimoto, M. et al., Chem. Pharm. Bull., 1962, 10, 572-575, (derivs)
• Iwai, I. et al., Chem. Pharm. Bull., 1966, 14, 1277, (synth)
• Rudy, B.C. et al., Anal. Profiles Drug Subst., 1973, 2, 467, (rev, synth, props)
• Brumfitt, W. et al., J. Infect. Dis., 1973, 128, 5778, (rev, pharmacol)
• Manzo, R.H. et al., J. Pharm. Sci., 1973, 62, 152, (uv)
• IARC Monog., 1980, 24, 285; Suppl. 7, 348; Suppl. 6, 502, (rev, tox)
• Bushby, S.R.M. et al., Handb. Exp. Pharmacol., 1983, 64, 75; 163; 185, (revs)
• Bult, A., Pharm. Weekbl., Sci. Ed., 1983, 5, 77, (cmr, tautom)
• Maury, L. et al., Can. J. Chem., 1985, 63, 3012, (cryst struct, ir, Raman)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 1514; 3212
• Kirk-Othmer Encycl. Chem. Technol., 4th edn., Wiley, 1991, 2, 876
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 208
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, SNK000