Mequitazine

• Catalog No.: Bio-0800
• CAS Number: 29216-28-2
• M. F.: C20H22N2S
• M. W.: 322.46708

SYNONYMS

• IUPAC name: 10-{1-azabicyclo[2.2.2]octan-3-ylmethyl}-10H-phenothiazine
• IUPAC Traditional name: 10-{1-azabicyclo[2.2.2]octan-3-ylmethyl}-10H-phenothiazine
• Synonyms: Vigigan; Kitazemin; Instotal; Zesulan; Mequitazinum; Virginan

DATABASE IDS

• CAS Number: 29216-28-2

PROPERTIES

• Application(s): Antiallergic agent
• Mechanism of Action: Mequitazine binds to the histamine H1 receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract.
• Mechanism of Action: This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine

REFERENCES

• Ger. Pat., 1970, 2 009 555; CA, 73, 131017r, (synth)
• Uzan, A. et al., Xenobiotica, 1976, 6, 633, (metab)
• Uzan, A. et al., J. Pharm. Pharmacol., 1979, 31, 701, (pharmacol)
• Ger. Pat., 1985, 3 509 460; CA, 104, 148890, (synth, Mequitazine)
• Criscuolo, M. et al., Eur. J. Pharmacol., 1986, 126, 81, (pharmacol, Mequitazine)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 5665, (synonyms)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 942
• Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, MCJ400